Effect of metformin on semen quality

Authors

  • Saleem Ali Banihani Jordan University of Science and Technology; Department of Medical Laboratory Sciences

DOI:

https://doi.org/10.1590/s1984-82502016000400002

Abstract

Various studies have linked metformin, a universally antidiabetic drug, with semen quality; however, such a direct link has not been established. This review systematically addresses and summarizes the effect of metformin on semen quality, particularly sperm function. We searched the MEDLINE electronic database for English articles and abstracts containing the key words 'metformin' and 'sperm', and relevant articles were reviewed. In summary, metformin appears to have improved and provided positive impact on sperm quality. This effect may be due to the ability of metformin to reduce oxidative stress and lipid peroxidation, enhance 5'-AMP activated protein kinase activity, and restore the normal levels of pituitary-gonadal hormones. However, further clinical research is still necessary to confirm such effect.

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Published

2016-12-01

Issue

Section

Review

How to Cite

Effect of metformin on semen quality . (2016). Brazilian Journal of Pharmaceutical Sciences, 52(4), 591-594. https://doi.org/10.1590/s1984-82502016000400002