Pullulan as a stabilizer agent of polymeric nanocapsules for drug delivery

Authors

  • Janaíne Micheli Chassot Federal University of Santa Maria; Department of Industrial Pharmacy
  • Luana Mota Ferreira Federal University of Santa Maria; Department of Industrial Pharmacy
  • Felipe Pereira Gomes Federal University of Santa Maria; Department of Industrial Pharmacy
  • Cristiane de Bona da Silva Federal University of Santa Maria; Department of Industrial Pharmacy
  • Leandro Tasso University of Caxias do Sul; Institute of Biotechnology
  • Letícia Cruz Federal University of Santa Maria; Department of Industrial Pharmacy

DOI:

https://doi.org/10.1590/s1984-82502016000400018

Abstract

Polymeric stabilizers have received attention in the preparation of nanostructured systems due to their ability to enhance formulation stability. Considering this, the objective of this work was to prepare poly(ε-caprolactone) nanocapsules using the pullulan as a polymeric stabilizer. The nanocapsules were prepared using the interfacial deposition method of preformed polymers and they were characterized in terms of pH, average diameter, polydispersity index, zeta potential, beclomethasone dipropionate content, encapsulation efficiency, photostability and drug release profiles. The formulations showed physicochemical characteristics consistent with nanocarriers for drug delivery such as: average diameter lower than 270 nm, polydispersity indexes lower than 0.2, negative zeta potential (-22.7 to -26.3 mV) and encapsulation efficiencies close to 100%. In addition, the nanocapsules were able to delay the beclomethasone dipropionate photodegradation under UVC radiation and by the dialysis bag diffusion technique, the nanocapsules were able to prolong the drug release. Thus, pullulan could be considered an interesting excipient to formulate polymeric nanocapsules.

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Published

2016-12-01

Issue

Section

Articles

How to Cite

Pullulan as a stabilizer agent of polymeric nanocapsules for drug delivery . (2016). Brazilian Journal of Pharmaceutical Sciences, 52(4), 735-740. https://doi.org/10.1590/s1984-82502016000400018