Unsatisfactory glycemic control in type 2 Diabetes mellitus patients: predictive factors and negative clinical outcomes with the use of antidiabetic drugs

Authors

  • Maria Aparecida Marczynski University of Sorocaba; Department of Pharmaceutical Sciences
  • Karine Laura Cortellazzi State University of Campinas; Dental School of Piracicaba; Department of Social Dentistry
  • Sílvio Barberato-Filho University of Sorocaba; Department of Pharmaceutical Sciences
  • Rogério Heládio Lopes Motta Anesthesiology and Therapeutics Dental School and Research Center; Department of Pharmacology
  • Alexandre Eduardo Franzin Vieira Pontifical Catholic University; Sorocaba Medical School
  • Maria Teresa Verrone Quilici Pontifical Catholic University; Sorocaba Medical School
  • Cristiane de Cássia Bergamaschi University of Sorocaba; Department of Pharmaceutical Sciences

DOI:

https://doi.org/10.1590/s1984-82502016000400026

Abstract

Many factors can interfere with glycemic control in patients with type 2 diabetes mellitus and this patient group has an increased risk of experiencing drug-related negative outcomes (DNO). The aim of this study was to identify the predictive factors of unsatisfactory glycemic control and DNO in this group of patients. A cross-sectional study was conducted collecting data from prescriptions and interviews with 100 patients of the Endocrinology Clinic of the Hospital Complex of Sorocaba, São Paulo, Brazil. Variables associated with unsatisfactory glycemic control were determined and the DNO associated with antidiabetic drugs identified. Age (<65 years) (OR=4.09), family history of diabetes (OR=3.24), use of combined therapy to treat diabetes (2-4 antidiabetic drugs) (OR=5.13) and presence of DNO (OR=5.92) were found to be predictive factors for poor patient glycemic control. DNO were observed in 49% of the patients and were caused predominantly by ineffectiveness in patients with poor glycemic control (p<0.05). There was no significant difference between groups (satisfactory and unsatisfactory glycemic control) for DNO caused by safety issues (p>;0.05). Characterization of the profile of patients with uncontrolled diabetes and of aspects associated with drug treatment can contribute to the planning of interventions to improve patient care.

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Published

2016-12-01

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Articles

How to Cite

Unsatisfactory glycemic control in type 2 Diabetes mellitus patients: predictive factors and negative clinical outcomes with the use of antidiabetic drugs . (2016). Brazilian Journal of Pharmaceutical Sciences, 52(4), 801-812. https://doi.org/10.1590/s1984-82502016000400026