Changes in weight and body fat after use of tetracycline and Lactobacillus gasseri in rats

Authors

  • Jorge José Marciano University of Sorocaba; Pharmacology Department
  • Fernando de Sá Del Fiol University of Sorocaba; Pharmacology Department
  • Alessandra Cristina Marciano Tardelli Ferreira University of Sorocaba; Pharmacology Department
  • Maria Cláudia Marques University of Sorocaba; Pharmacology Department
  • Luciane Lopes Santana University of Sorocaba; Pharmacology Department

DOI:

https://doi.org/10.1590/s2175-97902017000116059

Keywords:

Antimicrobials/evaluation, Obesity/tests, Gut microbiota/tests, Tetracyclines.

Abstract

Recent studies have shown a role of intestinal microbiota in obesity. The consumption of antibiotics in the last 70 years has led to changes in intestinal microbiota, which has led to weight gain and body fat accumulation. To evaluate the possibility of weight gain induced by antibiotics and the possible protective effect of probiotics, we divided 45 animals (Rattus norvegicus) into groups and administered the following treatments over two weeks: tetracycline, tetracycline + Lactobacillus gasseri, and NaCl. The animals were weighed over the course of 8 weeks, and at the end of the treatment period, they were measured and subjected to bioelectrical impedance analysis. The results show that the group receiving tetracycline alone had a higher body mass index (p=0.030), a greater Lee index (p=0.008), and a lower body water percentage than the control group, indicating a greater accumulation of body fat. The group receiving the probiotics with tetracycline presented similar results to the control group, indicating a possible protective effect of body fat accumulation in the group receiving tetracycline alone. The results show that tetracycline increased the concentration of body fat, and the use of probiotics was associated with an ability to protect the animals from the pro-obesity effect.

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Published

2017-01-01

Issue

Section

Articles

How to Cite

Changes in weight and body fat after use of tetracycline and Lactobacillus gasseri in rats. (2017). Brazilian Journal of Pharmaceutical Sciences, 53(1), e16059-. https://doi.org/10.1590/s2175-97902017000116059