Molecular epidemiology of influenza A(H1N1)PDM09 hemagglutinin gene circulating in São Paulo State , Brazil: 2016 anticipated influenza season

Authors

  • Katia Corrêa de Oliveira Santos Instituto Adolfo Lutz; Laboratório de Vírus Respiratórios; Núcleo de Doenças Respiratórias
  • Daniela Bernardes Borges da Silva Instituto Adolfo Lutz; Laboratório de Vírus Respiratórios; Núcleo de Doenças Respiratórias
  • Norio Augusto Sasaki Instituto Adolfo Lutz; Laboratório de Vírus Respiratórios; Núcleo de Doenças Respiratórias
  • Margarete Aparecida Benega Instituto Adolfo Lutz; Laboratório de Vírus Respiratórios; Núcleo de Doenças Respiratórias
  • Rebecca Garten Centers for Disease Control and Prevention; Influenza Division
  • Terezinha Maria de Paiva Instituto Adolfo Lutz; Laboratório de Vírus Respiratórios; Núcleo de Doenças Respiratórias

Keywords:

Influenza, National Influenza Surveillance Network, Molecular epidemiology, Vaccination strategy, Public health

Abstract

Compared to previous years, seasonal influenza activity commenced early in São Paulo State, Brazil, Southern hemisphere during the 2016 year. In order to investigate the genetic pattern of influenza A(H1N1)pdm09 in the State of Sao Paulo a total of 479 respiratory samples, collected in January by Sentinel Surveillance Units, were screened by real-time RT-PCR. A total of 6 Influenza viruses A(H1N1)pdm09 presenting ct values ≤ 30 were sequenced following phylogenetic analysis. The present study identified the circulation of the new 6B.1 subgroup (A/Sao Paulo/10-118/2016 and A/Sao Paulo/3032/2016). In addition, influenza A(H1N1)pdm09 group 6B has also been identified during January in the State of Sao Paulo. Despite amino acid changes and changes in potential glycosylation motifs, 6B.1 viruses were well inhibited by the reference ferret antiserum against A/California/07/2009 virus, the A(H1N1)pdm09 component of the vaccine for the 2016 influenza season.

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Published

2017-01-01

Issue

Vol. 59 (2017)

Section

Brief Communication

How to Cite

Santos, K. C. de O., Silva, D. B. B. da, Sasaki, N. A., Benega, M. A., Garten, R., & Paiva, T. M. de. (2017). Molecular epidemiology of influenza A(H1N1)PDM09 hemagglutinin gene circulating in São Paulo State , Brazil: 2016 anticipated influenza season. Revista Do Instituto De Medicina Tropical De São Paulo, 59, e9. https://revistas.usp.br/rimtsp/article/view/130566