Drug interactions among clinical and psychiatric drugs

Authors

  • Marco Antonio Marcolin Universidade de São Paulo; Hospital das Clínicas; Departamento de Psiquiatria
  • Maria da Graça Cantarelli Pontifícia Universidade Católica do Rio Grande do Sul; Hospital São Lucas; Serviço de Psiquiatria
  • Manoel Garcia Junior Instituto Abuchaim

DOI:

https://doi.org/10.1590/S0101-60832004000200003

Keywords:

Drug interaction, CYP, Cytochrome P450

Abstract

BACKGROUND/JUSTIFICATION: Studies point up the serious adverse reactions (ADR) as one of the six main causes of death of hospitalized patients in the United States. The most frequent ADR include the drug interaction. METHODS: twenty most used medications were compared, in a certain period of time, at the clinical sector of São Lucas Universitary Hospital of PUC-RS, to the fourteen most used ones at the Ambulatório de Depressão (ADe) of the same hospital. The research gathered information published since 1990 in Medline and Lilacs. RESULTS: several drug interactions were found among many of the studied medications, often involving the Cytochrome P450 System. CONCLUSION: the update of the medication on clinic use goes further than the expected results or the most frequent collateral effects.

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Published

2004-01-01

Issue

Vol. 31 No. 2 (2004)

Section

Original Articles

License

Once accepted for publication, the manuscript becomes permanent property of the Archives of Clinical Psychiatry. This copyright transfer subsumes exclusive and unlimited entitlement of the Archives of Clinical Psychiatry to publish and distribute the full contents of articles in whichever publishing medium, including press and electronic media, in Brazil and abroad.

Manuscripts are accepted with the understanding that the Editor and the editorial staff have the right to make revisions aimed at greater conciseness, clarity, and conformity with Journal style, of course without changing its content.

How to Cite

Drug interactions among clinical and psychiatric drugs . (2004). Archives of Clinical Psychiatry (São Paulo), 31(2), 70-81. https://doi.org/10.1590/S0101-60832004000200003