The treatment of bipolar depression

Authors

  • Beny Lafer Universidade de São Paulo; Faculdade de Medicina; Hospital das Clínicas; Instituto de Psiquiatria
  • Marcia Britto de Macedo Soares FMUSP; HC; Ipq; PROMAN

DOI:

https://doi.org/10.1590/S0101-60832005000700008

Keywords:

Bipolar depression, treatment, antidepressants

Abstract

The treatment of bipolar depression has been an area of debate. The use of antidepressants, particularly the triciclics, has been associated with worse clinical outcomes. Evidence points to a limited efficacy of traditional mood stabilizers such as lithium, valproate and carbamazepine in the treatment of bipolar depression. In cases where depression is more severe, there is evidence that antidepressants may be useful. The use of antidepressants should be in association with a mood stabilizer. New agents such as lamotrigine have been put forward as effective in the treatment of bipolar depression. Recent studies using lamotrigine suggest its efficacy and safety in the treatment of bipolar depression.

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Published

2005-01-01

Issue

Vol. 32 No. supl.1 (2005)

Section

Original Articles

License

Once accepted for publication, the manuscript becomes permanent property of the Archives of Clinical Psychiatry. This copyright transfer subsumes exclusive and unlimited entitlement of the Archives of Clinical Psychiatry to publish and distribute the full contents of articles in whichever publishing medium, including press and electronic media, in Brazil and abroad.

Manuscripts are accepted with the understanding that the Editor and the editorial staff have the right to make revisions aimed at greater conciseness, clarity, and conformity with Journal style, of course without changing its content.

How to Cite

The treatment of bipolar depression . (2005). Archives of Clinical Psychiatry (São Paulo), 32(supl.1), 49-55. https://doi.org/10.1590/S0101-60832005000700008