Depression and diabetes mellitus

Authors

  • Renério Fráguas Universidade de São Paulo; Faculdade de Medicina; Hospital das Clínicas; Instituto e Departamento de Psiquiatria
  • Simone Maria de Santa Rita Soares Universidade de São Paulo; Faculdade de Medicina; Hospital das Clínicas; Instituto e Departamento de Psiquiatria
  • Marcelo Delano Bronstein HC-FMUSP; Unidade de Neuroendocrinologia; Divisão de Clínica Médica; Serviço de Endocrinologia e Metabologia

DOI:

https://doi.org/10.1590/S0101-60832009000900005

Keywords:

Diabetes mellitus, depression, treatment, antidepressant, prevalence, prognosis

Abstract

Diabetes mellitus has an estimated prevalence of 7% among Brazilian population. Around 20% to 30% of these patients have a depressive disorder. Depression can work as risk factor to the development of diabetes, can worse its symptoms and interfere with self-care. When not adequately treated, depressive disorder in these patients tends to have high rates of recurrence. Among the available treatments literature shows a benefit of psychotherapy, mainly cognitive or cognitive-behavioral, in ameliorating depressive symptoms, but without impact on glycaemic control. Tryciclic antidepressants, especially those with more noradrenergic profile, and monoamino oxidase inhibitors are associated with worsening of glycaemic control. Bupropion shows no action on glucose blood levels and there are evidences that serotonin selective reuptake inhibitors may improve the glycaemic levels and reduce the recurrence, being good choices to treat these patients. Electroconvulsive therapy is an interesting treatment to these patients, but monitoring of blood glucose is recommended. We did not find data about other antidepressants.

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Published

2009-01-01

Issue

Vol. 36 No. supl.3 (2009)

Section

Reviews of Literature

License

Once accepted for publication, the manuscript becomes permanent property of the Archives of Clinical Psychiatry. This copyright transfer subsumes exclusive and unlimited entitlement of the Archives of Clinical Psychiatry to publish and distribute the full contents of articles in whichever publishing medium, including press and electronic media, in Brazil and abroad.

Manuscripts are accepted with the understanding that the Editor and the editorial staff have the right to make revisions aimed at greater conciseness, clarity, and conformity with Journal style, of course without changing its content.

How to Cite

Depression and diabetes mellitus . (2009). Archives of Clinical Psychiatry, 36(supl.3), 93-99. https://doi.org/10.1590/S0101-60832009000900005