Colinergic system: revisiting receptors, regulation and the relationship with Alzheimer disease, schizophrenia, epilepsy and smoking

Authors

  • Ana L. M. Ventura Universidade Federal Fluminense; Laboratório de Neuroquímica
  • Paula A. Abreu UFF; Programas de Pós-graduação em Neurociências e de Patologia; Laboratório de Neuroquímica e Laboratório de Antibióticos, Bioquímica e Modelagem Molecular
  • Rodrigo C. C. Freitas Universidade Federal Fluminense; Laboratório de Neuroquímica
  • Plínio C. Sathler UFF; Programas de Pós-graduação em Neurociências e de Patologia; Laboratório de Neuroquímica e Laboratório de Antibióticos, Bioquímica e Modelagem Molecular
  • Natália Loureiro UFF; Programas de Pós-graduação em Neurociências e de Patologia; Laboratório de Neuroquímica e Laboratório de Antibióticos, Bioquímica e Modelagem Molecular
  • Helena C. Castro UFF; Programas de Pós-graduação em Neurociências e de Patologia; Laboratório de Neuroquímica e Laboratório de Antibióticos, Bioquímica e Modelagem Molecular

DOI:

https://doi.org/10.1590/S0101-60832010000200007

Keywords:

Receptors, cholinergic, Alzheimer disease, schizophrenia, epilepsy, smoking

Abstract

OBJECTIVES: To review articles regarding important topics about cholinergic system and its ionotropic and G-protein coupled receptors as well as their regulation, also enlightening its importance in central nervous system (CNS) development and in several neuropsychiatric conditions such as Alzheimer disease, schizophrenia, epilepsy and smoking. METHOD: Bibliographical research was completed through MedLine, LILACS, PubMed, ISI and the Fundação Oswaldo Cruz Library, RJ, specifically for 1914 to 2009, using the descritors: "receptors", "cholinergic", Alzheimer "disease", "schizophrenia", "epilepsy" and "smoking", in addition to the cross-reference of the articles selected and further analyses of bibliographical references on the theme. RESULTS: Currently literature describes important effects of nicotinic and muscarinic receptors activation on development of central nervous system (CNS). The protein G coupled receptors dessensibilization and internalization mediated by kinases have been described in proliferation, differentiation and cell death, and also in neurologic disorders. DISCUSSION: The importance of the cholinergic system and its relationship with pathologies such as Alzheimer disease, schizophrenia, epilepsy is evident. The data produced so far may help on planning medicaments more specific for these pathologies treatment.

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Published

2010-01-01

Issue

Vol. 37 No. 2 (2010)

Section

Reviews of Literature

License

Once accepted for publication, the manuscript becomes permanent property of the Archives of Clinical Psychiatry. This copyright transfer subsumes exclusive and unlimited entitlement of the Archives of Clinical Psychiatry to publish and distribute the full contents of articles in whichever publishing medium, including press and electronic media, in Brazil and abroad.

Manuscripts are accepted with the understanding that the Editor and the editorial staff have the right to make revisions aimed at greater conciseness, clarity, and conformity with Journal style, of course without changing its content.

How to Cite

Colinergic system: revisiting receptors, regulation and the relationship with Alzheimer disease, schizophrenia, epilepsy and smoking . (2010). Archives of Clinical Psychiatry, 37(2), 66-72. https://doi.org/10.1590/S0101-60832010000200007