Absence of an association between serum interleukin-6 and brain-derived neurotrophic factor in drug-naïve first-episode major depression

Authors

  • Reiji Yoshimura University of Occupational and Environmental Health, Japan 1-1 Iseigaoka, Yahatanishiku, Kitakyushu, Fukuoka 8078555, Japan https://orcid.org/0000-0002-7637-5576
  • Naomichi Okamoto University of Occupational and Environmental Health, Japan 1-1 Iseigaoka, Yahatanishiku, Kitakyushu, Fukuoka 8078555, Japan
  • Yuki Kinishi University of Occupational and Environmental Health, Japan 1-1 Iseigaoka, Yahatanishiku, Kitakyushu, Fukuoka 8078555, Japan
  • Atsuko Ikenouchi University of Occupational and Environmental Health, Japan 1-1 Iseigaoka, Yahatanishiku, Kitakyushu, Fukuoka 8078555, Japan

DOI:

https://doi.org/10.15761/0101-60830000000312

Keywords:

interleukin-6, major depression, neuroinflammation, brain-derived neurotrophic factors

Abstract

Peripheral and central cytokine interleukin-6 (IL-6) levels play an important role in the pathophysiology of major depression (MD). We investigated the association between serum levels of IL-6 and brain-derived neurotrophic factor (BDNF) in drug-naïve, first-episode patients with MD. This study included 28 patients (male/female: 11/17; mean [standard deviation] age, 46.7 [11.9] years) who met the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria for MD without any physical diseases. We evaluated the severity of depression using the Hamilton Rating Scale for Depression. No associations were found between serum levels of IL-6 and BDNF (r=-0.102, P =0.605). These results suggest that IL-6 does not influence BDNF and vice versa, but both act in a peripheral manner.

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Published

2021-10-01

Issue

Vol. 48 No. 5 (2021)

Section

Original Article

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How to Cite

Absence of an association between serum interleukin-6 and brain-derived neurotrophic factor in drug-naïve first-episode major depression. (2021). Archives of Clinical Psychiatry (São Paulo), 48(5), 229-230. https://doi.org/10.15761/0101-60830000000312