Large-scale analyses of schizophrenia proteome

Authors

  • Bruno M. Oliveira Universidade Estadual de Campinas; Departamento de Bioquímica; Laboratório de Proteômica
  • Daniel Martins-de-Souza Universidade Ludwig Maximilians de Munique; Instituto Max Planck de Psiquiatria

DOI:

https://doi.org/10.1590/S0101-60832012005000004

Keywords:

Proteomics, schizophrenia, mass spectrometry, energy metabolism, oligodendrocytes

Abstract

Valuable knowledge about schizophrenia has been recently generated for deciphering its pathobiology and revealing biomarkers. However, efforts are still needed, especially if we take in account that this debilitating mental disorder affects approximately 30 million people worldwide. Considering that schizophrenia is a result of a complex interaction among environmental factors altered gene function and systematic differential protein expression, proteomics is likely to be a suitable tool for studying this disorder. Here we synthetize the main findings by proteomic studies and further directions to be taken in order to better comprehend the biochemistry of schizophrenia as well as reveal biomarkers. In addition, we summarize proteomic methodologies used in such studies.

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Published

2013-01-01

Issue

Vol. 40 No. 1 (2013)

Section

Reviews of Literature

License

Once accepted for publication, the manuscript becomes permanent property of the Archives of Clinical Psychiatry. This copyright transfer subsumes exclusive and unlimited entitlement of the Archives of Clinical Psychiatry to publish and distribute the full contents of articles in whichever publishing medium, including press and electronic media, in Brazil and abroad.

Manuscripts are accepted with the understanding that the Editor and the editorial staff have the right to make revisions aimed at greater conciseness, clarity, and conformity with Journal style, of course without changing its content.

How to Cite

Large-scale analyses of schizophrenia proteome. (2013). Archives of Clinical Psychiatry, 40(1), 16-19. https://doi.org/10.1590/S0101-60832012005000004