Indeterminate cell histiocytosis successfully treated with phototherapy

Authors

  • Maria Claudia Nogueira Zerbini University of São Paulo. Faculty of Medicine. Department of Pathology
  • Mirian Nacagami Sotto University of São Paulo. Faculty of Medicine. Department of Pathology
  • Fernando Peixoto Ferraz de Campos University of São Paulo. Hospital Universitário. Internal Medicine Division
  • Andre Neder Ramires Abdo Instituto do Câncer de São Paulo. Hematologic Oncology Department
  • Juliana Pereira Instituto do Câncer de São Paulo. Hematologic Oncology Department Universisity of São Paulo. Faculty of Medicine. Department of Hematology
  • José Antônio Sanches Junior University of São Paulo. Hospital das Clínicas. Faculty of Medicine. Dermatology Department
  • Jade Cury Martins University of São Paulo. Hospital das Clínicas. Faculty of Medicine. Dermatology Department

DOI:

https://doi.org/10.4322/acr.2016.038

Keywords:

Histiocytosis, Skin Diseases, Phototherapy

Abstract

First described in 1985, intermediate cell histiocytosis is a rare disorder of the cutaneous dendritic cell group with a varied clinical presentation and evolution. The pathologic substrate is constituted by the proliferation of indeterminate cells (ICs) that are immunophenotypically characterized by the positivity of CD1a, CD68, and faint/focal S100, plus the negativity for CD207 (langerin). The authors present the case of a healthy elderly woman who presented generalized dome-shaped reddish cutaneous nodules over her trunk, neck, face, and extremities over a period of 18 months. A laboratory and imaging work-up ruled out internal involvement. The skin biopsy was consistent with IC histiocytosis. The patient was treated with narrowband ultraviolet B phototherapy, which resulted in an excellent short-term outcome

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Published

2016-06-11

Issue

Vol. 6 No. 2 (2016)

Section

Article / Clinical Case Report

License

Authors of articles published by Autopsy and Case Report retain the copyright of their work without restrictions, licensing it under the Creative Commons Attribution License - CC-BY, which allows articles to be re-used and re-distributed without restriction, as long as the original work is correctly cited.

How to Cite

Zerbini, M. C. N., Sotto, M. N., Campos, F. P. F. de, Abdo, A. N. R., Pereira, J., Sanches Junior, J. A., & Martins, J. C. (2016). Indeterminate cell histiocytosis successfully treated with phototherapy. Autopsy and Case Reports, 6(2), 33-38. https://doi.org/10.4322/acr.2016.038