Mantle cell lymphoma presenting with lethal atraumatic splenic rupture

Authors

DOI:

https://doi.org/10.4322/acr.2021.340

Keywords:

Lymphoma, Mantle-Cell, Splenic Rupture, Cyclin D, Lymphoma, Malignant

Abstract

Mantle cell lymphoma is characterized by t(11;14) with CCND1-IGH fusion and manifests with a spectrum of disease ranging from relatively indolent to aggressive. Here, we present a case of pleomorphic mantle cell lymphoma with three fusion signals that presented with lethal atraumatic splenic rupture. We discuss on the implications of variant CCND1 signal patterns as well as the epidemiology and pathophysiology of atraumatic splenic rupture.

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References

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Published

2021-11-18

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Section

Clinical Case Report

How to Cite

Eyerer, F. ., Gardner, J.-A., & Devitt, K. A. (2021). Mantle cell lymphoma presenting with lethal atraumatic splenic rupture. Autopsy and Case Reports, 11, e2021340. https://doi.org/10.4322/acr.2021.340