Papillary renal cell carcinoma with extensive spindle cell foci: mimicker of mucinous tubular and spindle cell carcinoma
DOI:
https://doi.org/10.4322/acr.2024.479Keywords:
Carcinoma, Papillary, Hippo Signaling Pathway, Immunohistochemistry, Kidney Neoplasms, NephrectomyAbstract
Papillary renal cell carcinoma (PRCC) is the second most common renal cell carcinoma (RCC), accounting for 10-15% of cases. Mucinous tubular and spindle cell carcinoma (MTSCC), on the other hand, accounts for only 1% of renal tumors and has a more favorable prognosis compared to PRCC. We report a 75-year-old female with a left upper pole solid renal mass displaying features of both papillary renal cell carcinoma (PRCC) and mucinous tubular and spindle cell carcinoma (MTSC). In this case, a shaggy luminal surface, multiple papillations, and psammoma bodies, absence of E-cadherin expression, and strong CD10 expression favored PRCC. Both immunohistochemistry and genomic analysis are critical to diagnose and differentiate tumors that may have overlapping features accurately.Downloads
References
Ren Q, Wang L, Al-Ahmadie HA, et al. Distinct genomic copy number alterations distinguish mucinous tubular and spindle cell carcinoma of the kidney from papillary renal cell carcinoma with overlapping histologic features. Am J Surg Pathol. 2018;42(6):767-77. http://dx.doi.org/10.1097/PAS.0000000000001038. PMid:29462091.
Mendhiratta N, Muraki P, Sisk AE Jr, Shuch B. Papillary renal cell carcinoma: review. Urol Oncol. 2021;39(6):327-37. http://dx.doi.org/10.1016/j.urolonc.2021.04.013. PMid:34034966.
Lipworth L, Morgans AK, Edwards TL, et al. Renal cell cancer histological subtype distribution differs by race and sex. BJU Int. 2016;117(2):260-5. http://dx.doi.org/10.1111/bju.12950. PMid:25307281.
MacLennan GT, Farrow GM, Bostwick DG. Low-grade collecting duct carcinoma of the kidney: report of 13 cases of low-grade mucinous tubulocystic renal carcinoma of possible collecting duct origin. Urology. 1997;50(5):679-84. http://dx.doi.org/10.1016/S0090-4295(97)00335-X. PMid:9372874.
Nathany S, Monappa V. Mucinous tubular and spindle cell carcinoma: a review of histopathology and clinical and prognostic implications. Arch Pathol Lab Med. 2020;144(1):115-8. http://dx.doi.org/10.5858/arpa.2017-0506-RS. PMid:30865490.
Argani P, Netto GJ, Parwani AV. Papillary renal cell carcinoma with low-grade spindle cell foci: a mimic of mucinous tubular and spindle cell carcinoma. Am J Surg Pathol. 2008;32(9):1353-9. http://dx.doi.org/10.1097/PAS.0b013e31816a1c34. PMid:18670354.
Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM. The 2016 WHO classification of tumours of the urinary system and male genital organs. Part A: renal, penile, and testicular tumours. Eur Urol. 2016;70(1):93-105. http://dx.doi.org/10.1016/j.eururo.2016.02.029. PMid:26935559.
Mehra R, Vats P, Cieslik M, et al. Biallelic alteration and dysregulation of the hippo pathway in mucinous tubular and spindle cell carcinoma of the kidney. Cancer Discov. 2016;6(11):1258-66. http://dx.doi.org/10.1158/2159-8290.CD-16-0267. PMid:27604489.
Srigley JR, Delahunt B. Uncommon and recently described renal carcinomas. Mod Pathol. 2009;22(Suppl 2):S2-23. http://dx.doi.org/10.1038/modpathol.2009.70. PMid:19494850.
Yu FX, Zhao B, Guan KL. Hippo pathway in organ size control, tissue homeostasis, and cancer. Cell. 2015;163(4):811-28. http://dx.doi.org/10.1016/j.cell.2015.10.044. PMid:26544935.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Autopsy and Case Reports
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright
Authors of articles published by Autopsy and Case Report retain the copyright of their work without restrictions, licensing it under the Creative Commons Attribution License - CC-BY, which allows articles to be re-used and re-distributed without restriction, as long as the original work is correctly cited.
