Stability study of azithromycin in ophthalmic preparations

Authors

  • Andréia de Haro Moreno University of São Paulo State; School of Pharmaceutical Sciences; Department of Drugs and Medicines
  • Maria Fernanda Conz da Silva University of São Paulo State; School of Pharmaceutical Sciences; Department of Drugs and Medicines
  • Hérida Regina Nunes Salgado University of São Paulo State; School of Pharmaceutical Sciences; Department of Drugs and Medicines

DOI:

https://doi.org/10.1590/S1984-82502009000200005

Keywords:

Azithromycin^i1^sstability st, Bioassay, Photodegradation, Ophthalmic preparations

Abstract

A stability study of azithromycin in ophthalmic preparations was developed by submission to different types of light, temperature and pH, using the biodiffusion assay (cylinder 3 x 3) for the quantifications. Bacillus subtilis, ATCC 9372, was used as test organism. The used concentration range was of 50 to 200 µg/mL. The study demonstrated that the drug suffered degradation when submitted to the ultraviolet light, germicide light, solar luminosity, acid solution, basic solution and hydrogen peroxide solution. The results were analyzed by the analysis of variance (ANOVA).

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Published

2009-06-01

Issue

Vol. 45 No. 2 (2009)

Section

Original Papers

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on line journal has open and free access.

How to Cite

Stability study of azithromycin in ophthalmic preparations . (2009). Brazilian Journal of Pharmaceutical Sciences, 45(2), 219-226. https://doi.org/10.1590/S1984-82502009000200005