Existence of advanced glycation / lipoxidation end-products in parenteral nutrition solutions and effects of infusion conditions on their levels

Authors

DOI:

https://doi.org/10.1590/

Keywords:

Degradation products;, Parenteral nutrition solution;, Advanced glycation end-products;, N-carboxymethyl lysine;, 4-hydroxynonenal

Abstract

Infusion solutions must be stable from the production stage until the infusion stage. Some infusion fluids contain degradation products, known as advanced glycation end products (AGEs); however, it is unknown whether AGEs exist in parenteral nutrition solutions. We aimed to investigate this question and test the effect of infusion conditions on AGE formation in parenteral nutrition solution. Nine parenteral nutrition solutions were supplied by the pharmacy with which we collaborated. To simulate the infusion conditions, the solutions were held in a patient room with standard lighting and temperature for 24 hours. Samples were taken at the beginning (group A) and the end (24th hour, group B) of the infusion period. The degradation products were 3-deoxyglucosone, pentosidine, N-carboxymethyl lysine, and 4-hydroxynonenal, which we investigated by high-performance liquid chromatography-mass spectrometry (LC-MS) and Q-TOF LC/MS methods. Two of four degradation products, 4-hydroxynonenal and N-carboxymethyl lysine, were detected in all samples, and Group B had higher levels of both compounds compared to Group A, who showed that the quantities of these compounds increased in room conditions over time. The increase was significant for 4-hydroxynonenal (p=0.03), but not for N-carboxymethyl lysine (p=0.23). Moreover, we detected in the parenteral nutrition solutions a compound that could have been 4-hydroxy-2-butynal or furanone.

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Author Biographies

  • Nurettin Kahramansoy , Abant İzzet Baysal University. Faculty of Medicine
    made substantial contributions to the conception and design of the work drafted the work and revised it critically for important intellectual content.
  • Mustafa Çelebi̇er, Hacettepe University. Faculty of Pharmacy
    made substantial contributions to the conception and design of the work made the acquisition, analysis, and interpretation of data drafted the work and revised it critically for important intellectual content.

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Published

2023-08-28

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How to Cite

Existence of advanced glycation / lipoxidation end-products in parenteral nutrition solutions and effects of infusion conditions on their levels. (2023). Brazilian Journal of Pharmaceutical Sciences, 59, e23017. https://doi.org/10.1590/