Antimicrobial stewardship program at a university hospital: an analysis of drug-related problems
DOI:
https://doi.org/10.1590/s2175-97902025e24541Keywords:
Antimicrobial stewardship, Pharmacovigilance, Drug-related problemsAbstract
To evaluate the pharmacotherapeutic interventions in antimicrobials, based on drug-related problems (DRP) implemented by the antimicrobial stewardship program (ASP). This is a posthoc analysis carried out between January 2018 and December 2019 in a University public trauma hospital. The DRP methodology was used to assess correct pharmacotherapy of antibiotics and acceptance by clinicians. Acceptability was defined as accepted within 24 hours, accepted after 24 hours, not accepted, or not accepted with justification. A total of 4,951 prescriptions were audited, of which an average of 16% of interventions resulted in 35.1% in unnecessary medication, 22.6% in administration route. For acceptability, all demonstrated significance according to P values <0.0001. In safety, 49.0% of interventions were performed, 42.0% were needed, and 9.0% were effective. DRP analysis is an important resource to be used within the ASP, bringing significant results both in terms of patient safety and cost minimization.
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