Biochemical and haematological changes in synthetic cannabinoids and marijuana users; a retrospective evaluation
DOI:
https://doi.org/10.1590/s2175-97902026e20713Keywords:
Synthetic cannabinoids, Marijuana, Hematological parameters, Biochemical parameters, Neutrophil lymphocyte ratio, Platelet eosinophil ratioAbstract
Toxic and hazardeus substances have negative effects on both the environment and human health. In this study, we aimed to determine the relationship between use of synthetic cannabinoids and complete blood count parameters, neutrophil/ lymphocyte ratio (NLR), platelet/eosinophil ratio (PER) and platelet/lymphocyte ratio (PLR). 104 patients aged 18-65 years were evaluated retrospectively. Patients were divided into 3 groups; in control group (Group 1) no metabolites detected in urine samples, Group 2 positive for bonsai and Group3 positive for marijuana metabolites. Neutrophils, NLR and PER were higher, while %lymphocyte and %eosinophil were lower in Group 2 than Group 1 (p<0.05). The %eosinophil were lower, in contrast PER was higher in Group 2 compared to Group 3 (p<0.05). The findings of our study showed that bonsai consuming decreased lymphocyte percentage, eosinophil percentage while increasing neutrophil percentage, NLR and PER. We also found that marijuana consumption increased neutrophil percentage and NLR, and reduced lymphocyte percentage values. We believe that further research is needed to fully elucidate the effects of cannabinoid use on blood parameters.
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