Determination of in vitro antidiabetic effects of Zingiber officinale Roscoe

Authors

  • Naila Abdul Sattar University of Agriculture; Faculty of Sciences; Department of Chemistry and Biochemistry
  • Fatma Hussain University of Agriculture; Faculty of Sciences; Department of Chemistry and Biochemistry
  • Tahira Iqbal University of Agriculture; Faculty of Sciences; Department of Chemistry and Biochemistry
  • Munir Ahmad Sheikh University of Agriculture; Faculty of Sciences; Department of Chemistry and Biochemistry

DOI:

https://doi.org/10.1590/S1984-82502012000400003

Keywords:

Zingiber officinale^i1^spharmacogn, Zingiber officinale^i1^santidiabetic effe, Zingiber officinale^i1^sin vitro st, Diabetes mellitus, Hyperglycemia, Proteins^i1^sglycat, Glucose^i1^sdiffusion in vi

Abstract

Aqueous extracts of Zingiber officinale rhizomes were studied to evaluate their antidiabetic effects on protein glycation and on the diffusion of glucose in vitro in the present study. Zingiber officinale rhizome aqueous extract were examined at concentrations of 5, 10, 20 and 40 g/L. The antidiabetic effects were found to be dose-dependent. Antidiabetic potential of Zingiber officinale was mainly through inhibition of the glucose diffusion and to a limited extent by reducing the glycation. However, further studies are needed to determine in vitro effects of therapeutic potential by restraining postprandial glucose absorptions and plasma protein glycations in diabetic subjects.

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Published

2012-12-01

Issue

Vol. 48 No. 4 (2012)

Section

Articles

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on line journal has open and free access.

How to Cite

Determination of in vitro antidiabetic effects of Zingiber officinale Roscoe . (2012). Brazilian Journal of Pharmaceutical Sciences, 48(4), 601-607. https://doi.org/10.1590/S1984-82502012000400003