Development studies of captopril certified reference material

Autores

  • Raquel Nogueira Brazilian National Institute of Metrology, Standardization and Industrial Quality; Chemical Metrology Division; Organic Analysis Laboratory
  • Eliane Cristina Pires do Rego Brazilian National Institute of Metrology, Standardization and Industrial Quality; Chemical Metrology Division; Organic Analysis Laboratory
  • Marcus Vinicius Barreto Sousa Brazilian National Institute of Metrology, Standardization and Industrial Quality; Chemical Metrology Division; Organic Analysis Laboratory
  • Wagner Wollinger Brazilian National Institute of Metrology, Standardization and Industrial Quality; Chemical Metrology Division; Organic Analysis Laboratory
  • Thaís Elias da Silva Brazilian National Institute of Metrology, Standardization and Industrial Quality; Chemical Metrology Division; Organic Analysis Laboratory
  • Gabriela Fernandes Moreira Brazilian National Institute of Metrology, Standardization and Industrial Quality; Materials Metrology Division
  • Juliano Smanioto Barin Brazilian National Institute of Metrology, Standardization and Industrial Quality; Chemical Metrology Division; Organic Analysis Laboratory
  • Luciane Varini Laporta Brazilian National Institute of Metrology, Standardization and Industrial Quality; Chemical Metrology Division; Organic Analysis Laboratory
  • Márcia Foster Mesko Brazilian National Institute of Metrology, Standardization and Industrial Quality; Chemical Metrology Division; Organic Analysis Laboratory
  • Celso Figueiredo Bittencourt Brazilian National Institute of Metrology, Standardization and Industrial Quality; Chemical Metrology Division; Organic Analysis Laboratory
  • Janaína Marques Rodrigues Brazilian National Institute of Metrology, Standardization and Industrial Quality; Chemical Metrology Division; Organic Analysis Laboratory
  • Valnei Smarçaro da Cunha Brazilian National Institute of Metrology, Standardization and Industrial Quality; Chemical Metrology Division; Organic Analysis Laboratory

DOI:

https://doi.org/10.1590/S1984-82502011000200015

Palavras-chave:

Captopril^i2^sanálise qualitat, Fármacos^i2^sPadrões de Referên, Fármacos^i2^scontrole analítico de qualid, Cromatografia Líquida de Alta Eficiência^i2^sanálise qualitat, Medicamentos^i2^scontamina

Resumo

Este artigo descreve os estudos realizados com o candidato a Material de Referência Certificado (MRC) de captopril, primeiro MRC de fármacos no Brasil, incluindo a determinação de impurezas (orgânicas, inorgânicas e voláteis), testes de homogeneidade, testes de estabilidade de curta e longa duração, cálculo do teor de captopril por balanço de massa e estimativa da incerteza de medição associada ao valor certificado.

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Publicado

2011-06-01

Edição

v. 47 n. 2 (2011)

Seção

Artigos

Licença

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on-line journal has open and free access.

Como Citar

Development studies of captopril certified reference material . (2011). Brazilian Journal of Pharmaceutical Sciences, 47(2), 339-350. https://doi.org/10.1590/S1984-82502011000200015