Impact of supplemental vitamins and natural honey for treatment of COVID-19
a review
DOI:
https://doi.org/10.1590/s2175-97902022e20607Palavras-chave:
Natural productsResumo
The main aim of the paper is to assess whether vitamin C, vitamin D, and natural honey can be administered in the course of the COVID-19 pandemic for promising in line methods with recent evidence. Both systematic literature and clinical trial identification were conducted by searching various databases. A total 58 articles and 29 clinical trials were selected wherein 11 for vitamin C, 16 for vitamin D, and 2 for natural honey were identified for analysis. The high doses of vitamin C (i.e. ‘200 mg/kg body weight/day, divided into 4 doses’) has been found to reduce COVID-19 lung damage, various flu infections. Additionally, the high doses of vitamin C can shorten around 7.8% stay in the intensive care unit. At the same time, vitamin D can effectively protect from lung injury and acute respiratory infections whereas vitamin D deficiency severely affects 75% of the institutionalized people (serum 25(OH) D < 25 nmol/L). Meanwhile, natural honey which contains proteins (0.1-0.4%); ash (0.2%); water (15-17%) has potential antiviral effects and the ability to improve immunity. Therefore, the administration of vitamins and honey is the promising evidence-based approach for reducing fatalities, saving lives, and bringing the COVID-19 pandemic to a rapid end. It is believed that the utilization of vitamin C, vitamin D, and natural honey with the current treatment may be effective in treating COVID-19-caused fatal complications such as pneumonia. Therefore, high-level clinical studies are required on COVID-19 to administrate the effects of vitamins and natural honey
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Abbas AC, Alwaeli AZ, Abbas EC, Mohamed A. Effect of honey consumed of COVID-19 patients over time and changes in concentrations levels of antioxidants and oxidative stress in the patients over time and compare with control group. Ann Romanian Soc Cell Biol. 2021;25(6):8961-74.
Abrishami A, Dalili N, Torbati PM, Asgari R, Arab-Ahmadi M, Behnam B, et al. Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: a retrospective study. Eur J Nutr. 2021;60(4):2249-57.
Abu-Amer Y, Bar-Shavit Z. Impaired bone marrow-derived macrophage differentiation in vitamin D deficiency. Cell Immunol. 1993;151(2):356-68.
Adami S, Bertoldo F, Braga V, Fracassi E, Gatti D, Gandolini G, et al. 25-hydroxy vitamin D levels in healthy premenopausal women: association with bone turnover markers and bone mineral density. Bone. 2009;45(3):423-6.
Ahmed N, Araf Y, Ullah MA. Prospects of vitamin D in the treatment of COVID-19 patient and improving maternal and child health during pandemic. J Adv Biotechnol Exp Ther. 2021;4(2):133-48.
Ahmed S, Othman NH. Review of the medicinal effects of tualang honey and a comparison with manuka honey. Malays J Med Sci. 2013;20(3):6-13.
Ali I, Alharbi OM. COVID-19: Disease, management, treatment, and social impact. Sci Total Environ. 2020;728:138861.
Al-Waili NS. Topical honey application vs. acyclovir for the treatment of recurrent herpes simplex lesions. Med Sci Monit. 2004;10(8):MT94-8.
Awad OG, Hamad AM. Honey can help in herpes simplex gingivostomatitis in children: Prospective randomized double blind placebo controlled clinical trial. Am J Otolaryngol. 2018;39(6):759-63.
Bhagavathula AS, Aldhaleei WA, Rahmani J, Mahabadi MA, Bandari DK. Knowledge and Perceptions of COVID-19 Among Health Care Workers: Cross-Sectional Study. JMIR Public Health Surveill. 2020;6(2):e19160.
Braithwaite MC, Kumar P, Tyagi C, Tomar LK, Choonara YE, Pillay V. Vitamin D therapy and related metabolomics: is the calciferol dose and form the only requirements for successful clinical therapeutics? Med Hypotheses. 2013;81(4):656-63.
Cai Y, Li YF, Tang LP, Tsoi B, Chen M, Chen H, et al. A new mechanism of vitamin C effects on A/FM/1/47 (H1N1) virus-induced pneumonia in restraint-stressed mice. Biomed Res Int. 2015;2015:675149.
Carr AC, Maggini S. Vitamin C and immune function. Nutrients. 2017;9(11):1211-36.
Cheng RZ. Can early and high intravenous dose of vitamin C prevent and treat coronavirus disease 2019 (COVID-19)? Med Drug Dev. 2020;5:100028.
Cui C, Xu P, Li G, Qiao Y, Han W, Geng C, et al. Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: role of renin- angiotensin system. Redox Biol. 2019;26:101295.
Elste V, Troesch B, Eggersdorfer M, Weber P. Emerging evidence on neutrophil motility supporting its usefulness to define vitamin C intake requirements. Nutrients . 2017;9(5):503.
El-Sayed SM, Almaramhy HH, Aljehani YT, Okashah AM, El-Anzi ME, AlHarbi MB, et al. TaibUVID for Minimizing COVID-19 Fatalities and Morbidity: An Evidence-based Approach for Better Outcomes (A Treatment Protocol). Am J Public Health. 2020;8(2):54-60.
EU Clinical Trials Register. [cited 2020 Jun 2]. Available from: Available from: https://www.clinicaltrialsregister.eu
» https://www.clinicaltrialsregister.eu
Eurosurveillance Editorial Team. Note from the editors: World Health Organization declares novel coronavirus (2019-nCoV) sixth public health emergency of international concern. Eurosurveillance. 2020;25(5):200131e.
Farjana M, Moni A, Sohag AA, Hasan A, Hannan MA, Hossain MG, et al. Repositioning vitamin C as a promising option to alleviate complications associated with COVID-19. Infect Chemother. 2020;52(4):461.
Fowler III AA, Kim C, Lepler L, Malhotra R, Debesa O, Natarajan R, et al. Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome. World J Crit Care Med. 2017;6(1):85-90.
Gao D, Xu M, Wang G, Lv J, Ma X, Guo Y, et al. The efficiency and safety of high-dose vitamin C in patients with COVID-19: A retrospective cohort study. Aging (Albany NY). 2021;13(5):7020-34.
Gruber-Bzura BM. Vitamin D and influenza-prevention or therapy? Int J Mol Sci. 2018;19(8):2419.
Güleşci N, Aygül İ. Beslenmede yer alan antioksidan ve fenolik madde içerikli çerezler. Gümüşhane Üni Sağlık Bilimleri Derg. 2016;5(1):109-29.
Hançer AT, Yilmaz P, Yilmaz M. New Coronavirus (2019- nCoV/COVID-19) and Vitamin C. Turk Klin Tip Bilimleri Derg. 2020;40(2):260-4.
Helming L, Böse J, Ehrchen J, Schiebe S, Frahm T, Geffers R, et al. 1α, 25-dihydroxyvitamin D3 is a potent suppressor of interferon γ-mediated macrophage activation. Blood. 2005;106(13):4351-8.
Hemilä H, Chalker E. Vitamin C can shorten the length of stay in the ICU: a meta-analysis. Nutr. 2019;11(4):708.
Hossain KS, Hossain MG, Moni A, Rahman MM, Rahman UH, Alam M, et al. Prospects of honey in fighting against COVID-19: pharmacological insights and therapeutic promises. Heliyon. 2020;6(12):e05798.
Ilie PC, Stefanescu S, Smith L. The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality. Aging Clin Exp Res. 2020;32:1195-8.
Information on Clinical Trials and Human Research Studies. [cited 2020 Jun 2]. Available from: Available from: https://clinicaltrials.gov
Kalediene L, Baz M, Liubaviciute A, Biziuleviciene G, Grabauskyte I, Bieliauskiene R, et al. Antiviral effect of honey extract Camelyn against SARS-CoV-2. J Adv Biotechnol Exp Ther . 2021;4(3):290-7.
Kim H, Jang M, Kim Y, Choi J, Jeon J, Kim J, et al. Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/ H1N1 infection. J Pharm Pharmacol. 2016;68(3):406-20.
Koshiba T, Yasukawa K, Yanagi Y, Kawabata SI. Mitochondrial membrane potential is required for MAVS- mediated antiviral signaling. Sci Signal. 2011;4(158):ra7.
Kuba K, Imai Y, Penninger JM. Angiotensin-converting enzyme 2 in lung diseases. Curr Opin Pharmacol. 2006;6(3):271-6.
Kumar P, Kumar M, Bedi O, Gupta M, Kumar S, Jaiswal G, et al. Role of vitamins and minerals as immunity boosters in COVID-19. Inflammopharmacol. 2021;29:1001-16.
Lai CC, Shih TP, Ko WC, Tang HJ, Hsueh PR. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and corona virus disease-2019 (COVID-19): the epidemic and the challenges. Int J Antimicrob Agents. 2020;55(3):105924.
Li J. Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis. Crit Care. 2018;22(1):258.
Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med. 2020;382(13):1199-1207.
Lips P, Cashman KD, Lamberg-Allardt C, Bischoff-Ferrari HA, Obermayer-Pietsch B, Bianchi ML, et al. Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European Calcified Tissue Society. Eur J Endocrinol. 2019;180(4):P23-54.
Liu Q, Gao Y, Ci X. Role od Nrf2 and its activators in respiratory diseases. Oxid Med Cell Longevity. 2019;2019:7090534.
MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985;76(4):1536-8.
Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas J. Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: a retrospective before-after study. Chest. 2017;151(6):1229-38.
Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. Br Med J. 2017;356:i6583.
Münstedt K. Bee products and the treatment of blister-like lesions around the mouth, skin and genitalia caused by herpes viruses-A systematic review. Complement Ther Med. 2019;43:81-4.
Nabzdyk CS, Bittner EA. Vitamin C in the critically ill- indications and controversies. World J Crit Care Med . 2018;7(5):52-61.
Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol. 2014;144:138-45.
Rabby MII. Current drugs with potential for treatment of COVID-19: A literature review. J Pharm Pharm Sci. 2020;23(1):58-64.
Rabby MII, Hossain F, Akhi IJ, Amin SS, Khan A. Understanding of General People about COVID-19: A Cross- Sectional Online Survey and Qualitative Presentation. Turk Klin Tip Bilimleri Derg . 2020;40(2):203-19.
Rabby MII, Hossain F. Study of ongoing registered clinical trials on COVID-19: a narrative review. Sao Paulo Med J. 2020;138(5):441-56.
Raftery T, A O’Morain C, O’Sullivan M. Vitamin D: new roles and therapeutic potential in inflammatory bowel disease. Curr Drug Metab. 2012;13(9):1294-302.
Ramanauskiene K, Stelmakiene A, Briedis V, Ivanauskas L, Jakštas V. The quantitative analysis of biologically active compounds in Lithuanian honey. Food Chem. 2012;132(3):1544-8.
Rao PV, Krishnan KT, Salleh N, Gan SH. Biological and therapeutic effects of honey produced by honey bees and stingless bees: a comparative review. Rev Bras Farmacogn. 2016;26(5):657-64.
Rogovskii VS. The linkage between inflammation and immune tolerance: interfering with inflammation in cancer. Curr Cancer Drug Targets. 2017;17(4):325-32.
Schievano E, Zuccato V, Finotello C, Vit P. Authenticity of Ecuadorian commercial honeys. Int J Biol Biomol Agric Food Biotechnol Eng. 2015;9(3):313-16.
Vit P, Deliza R, Pérez A. How a Huottuja (Piaroa) community perceives genuine and false honey from the Venezuelan Amazon, by free-choice profi le sensory method. Rev Bras Farmacogn . 2011;21(5):786-92.
Vit P, Vargas O, Valle FM. Meliponini biodiversity and medicinal uses of pot-honey from El Oro province in Ecuador. Emir J Food Agr. 2015;27(6):502-6.
Vit P, Uddin J, Zuccato V, Maza F, Schievano E. Entomological origin of honey discriminated by NMR chloroform extracts in Ecuadorian honey. Int J Biol Food Vet Agric Eng. 2015;9(5):437-40.
Watanabe K, Rahmasari R, Matsunaga A, Haruyama T, Kobayashi N. Anti-influenza viral effects of honey in vitro: potent high activity of manuka honey. Arch Med Res. 2014;45(5):359-65.
World Health Organization. Novel coronavirus (COVID-19) situation. [cited 2020 Jul 17]. Available from: Available from: https://experience. arcgis.com/experience/685d0ace521648f8a5beeeee1b9125cd
» https://experience. arcgis.com/experience/685d0ace521648f8a5beeeee1b9125cd
Xudong X, Junzhu C, Xingxiang W, Furong Z, Yanrong L. Age-and gender-related difference of ACE2 expression in rat lung. Life Sci. 2006;78(19):2166-71.
Yaghoobi R, Kazerouni A. Evidence for clinical use of honey in wound healing as an anti-bacterial, anti-inflammatory anti-oxidant and anti-viral agent: A review. Jundishapur J Nat Pharm Prod. 2013;8(3):100-4.
Yin Y, Wunderink RG. MERS, SARS and other coronaviruses as causes of pneumonia. Respirol. 2018;23(2):130-7.
Zhang J, Rao X, Li Y, Zhu Y, Liu F, Guo G, et al. Pilot trial of high-dose vitamin C in critically ill COVID-19 patients. Ann Intensive Care. 2021;11:1-12.
Zhao B, Ling Y, Li J, Peng Y, Huang J, Wang Y, et al. Beneficial aspects of high dose intravenous vitamin C on patients with COVID-19 pneumonia in severe condition: a retrospective case series study. Ann Palliat Med. 2021;10:1599-609.
Zou Z, Yan Y, Shu Y, Gao R, Sun Y, Li X, et al. Angiotensin- converting enzyme 2 protects from lethal avian influenza A H5N1 infections. Nat Commun. 2014;5(1):1-7.
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