O uso da laserterapia em dose específica modula o processo inflamatório pulmonar em um modelo experimental de sepse em ratos
DOI:
https://doi.org/10.590/1809-2950/14589622042015Resumo
O objetivo do estudo foi determinar a eficácia da LLLT na diminuição do processo inflamatório pulmonar em ratos sépticos. Foram utilizados 32 ratos machos Wistar divididos em quatro grupos (n=8): controle (CG); sepse 24h (S24); sepse e tratamento com LLLT 30 J/cm² (S24L30); sepse e tratamento com LLLT 65 J/cm² (S24L65). A irradiação foi realizada imediatamente após a cirurgia na região anterior de traqueia e nas regiões ventrais do tórax, bilateralmente, logo abaixo das costelas. Foi realizada análise histológica do tecido pulmonar e o número de células inflamatórias foi quantificado. O grupo S24 apresentou um aumento de células inflamatórias comparado ao CG (p <0,05); S24L30 aumentou o número de células inflamatórias, enquanto S24L65 diminuiu este numero em relação ao S24 (ambos p <0,05); S24L65 diminui o numero de células inflamatórias comparado ao S24L30 (p<0.01). Concluiu-se que LLLT em dose específica de energia (30J/cm²) foi capaz de diminuir o número de células inflamatórias no tecido pulmonar em fase aguda da sepse.Downloads
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