Cardiovascular conditions and blood pressure as risk factors for adverse events during exercise in individuals with respiratory conditions
DOI:
https://doi.org/10.1590/Keywords:
Respiratory Tract Diseases, Exercise, Rehabilitation, Arterial Pressure, Hypotension, Orthostatic.Abstract
This study aimed to describe cardiovascular
conditions and compare repeated measurements of systemic
blood pressure (BP) and orthostatic hypotension (HO) as risk
factors for adverse events during exercise in individuals with
chronic respiratory conditions. This was a cross-sectional
study including individuals evaluated to participate in a
rehabilitation program. Comorbidities, signs, and symptoms
of self-reported cardiovascular conditions, resting BP
(measured simultaneously in both arms with at least three
measurements), and criteria for OH were assessed. Forty-two
individuals were included: 67% were women, with a mean
age of 53±18 years, and 38% had post-COVID-19 condition.
Cardiovascular conditions were reported by up to 76%
of individuals, but only 13 required medical clearance for
exercise. A total of 85% achieved reproducible BP results
with only three measurements. The difference in systolic
BP between the full protocol and a single measurement in
one arm was −2.2 mmHg (95% CI −4.2 to −0.2). Only one
individual (3%) presented OH. Cardiovascular conditions are
common in individuals with chronic respiratory conditions
but generally do not contraindicate exercise. Furthermore,
repeated BP measurements do not appear to be necessary
in this context.
Downloads
References
1. World Health Organization. Chronic respiratory diseases
[Internet]. 2019 [cited 2024 Apr 16]. Available from: https://www.
who.int/health-topics/chronic-respiratory-diseases#tab=tab_1
2. World Health Organization. Coronavirus disease (COVID-19): Post
COVID-19 condition [Internet]. 2023 [cited 2026 Mar 9]. Available
from: https://www.who.int/news-room/questions-and-answers/
item/coronavirus-disease-(covid-19)-post-covid-19-condition
3. McCarthy B, Casey D, Devane D, Murphy K, Murphy E, et al.
Pulmonary rehabilitation for chronic obstructive pulmonary
disease. Cochrane Database Syst Rev. 2015;2015(4).
doi: 10.1002/14651858.CD003793.pub3
4. Osadnik CR, Gleeson C, McDonald VM, Holland AE. Pulmonary
rehabilitation versus usual care for adults with asthma. Cochrane
Database Syst Rev. 2022;2022(8). doi: 10.1002/14651858.
CD013485.pub2
5. Jimeno-Almazán A, Pallarés JG, Buendía-Romero Á, Martínez-
Cava A, Franco-López F, et al. Post-COVID-19 syndrome and
the potential benefits of exercise. Int J Environ Res Public
Health. 2021;18(10):5329. doi: 10.3390/ijerph18105329
6. Spruit MA, Singh SJ, Garvey C, ZuWallack R, Nici L, et al.
An official american thoracic society/european respiratory
society statement: key concepts and advances in pulmonary
rehabilitation. Am J Respir Crit Care Med. 2013;188(8):e13-64.
doi: 10.1164/rccm.201309-1634ST
7. Suler Y, Dinescu LI. Safety Considerations During Cardiac and
Pulmonary Rehabilitation Program. Phys Med Rehabil Clin N
Am. 2012;23(2):433-40. doi: 10.1016/j.pmr.2012.02.013
8. World Physiotherapy. World physiotherapy response to
COVID-19 briefing paper 9. safe rehabilitation approaches for
people living with long covid: physical activity and exercise.
London: World Physiotherapy; 2021.
9. Barroso WKS, Rodrigues CIS, Bortolotto LA, Mota-Gomes
MA, Brandão AA, et al. Diretrizes Brasileiras de hipertensão
arterial – 2020 [Internet]. Arq Bras Cardiol. 2021 [cited 2026
Mar 9];116(3):516-658. Available from: https://abccardiol.org/
article/diretrizes-brasileiras-de-hipertensao-arterial-2020/
10. Malachias M, Souza W, Plavnik F, Rodrigues C, Brandão A, et
al. 7th Brazilian Guideline of Arterial Hypertension. Arq Bras
Cardiol. 2016;107(3):1-6. doi: 10.5935/abc.20160151
11. von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, et
al. The strengthening the reporting of observational studies in
epidemiology (STROBE) statement: guidelines for reporting
observational studies. J Clin Epidemiol. 2008;61(4):344-9.
doi: 10.1016/j.jclinepi.2007.11.008
12. Pereira CAC, Sato T, Rodrigues SC. New reference values for
forced spirometry in white adults in Brazil. J Bras Pneumol.
2007;33(4):397-406. doi: 10.1590/S1806-37132007000400008
13. Albuquerque VS, Dal Corso S, Amaral DP, Oliveira TMD, Souza
GF, et al. Normative values and reference equation for the
six-minute step test to evaluate functional exercise capacity:
a multicenter study. J Bras Pneumol. 2022;48(4):e20210511.
doi: 10.36416/1806-3756/e20210511
14. Camelier A, Rosa FW, Salmi C, Nascimento OA, Cardoso F,
et al. Using the Saint George’s Respiratory Questionnaire to
evaluate quality of life in patients with chronic obstructive
pulmonary disease: validating a new version for use in
Brazil. J Bras Pneumol. 2006;32(2):114-22. doi: 10.1590/
S1806-37132006000200006
15. Kovelis D, Segretti NO, Probst VS, Lareau SC, Brunetto AF, et
al. Validation of the Modified Pulmonary Functional Status and
Dyspnea Questionnaire and the Medical Research Council scale
for use in Brazilian patients with chronic obstructive pulmonary
disease. J Bras Pneumol. 2008;34(12):1008-18. doi: 10.1590/
S1806-37132008001200005
16. Charlson M, Szatrowski TP, Peterson J, Gold J. Validation of a
combined comorbidity index. J Clin Epidemiol. 1994;47(11):1245-
51. doi: 10.1016/0895-4356(94)90129-5
17. Ghorayeb N, Stein R, Daher DJ, Silveira AD, Ritt LEF, et al. The
Brazilian Society of Cardiology and Brazilian Society of Exercise
and Sports Medicine Updated Guidelines for Sports and
Exercise Cardiology – 2019. Arq Bras Cardiol. 2019;112(3):326-
68. doi: 10.5935/abc.20190048
18. American College of Sports Medicine. ACSM’s guidelines for
exercise testing and prescription. 11th ed. Philadelphia: Lippincott
Williams & Wilkins; 2021.
19. Global Initiative for Chronic Obstructive Lung Disease. Global
Strategy for the Diagnosis, Management, and Prevention
of Chronic Obstructive Pulmonary Disease – 2024 report
[Internet]. 2023 [cited 2026 Mar 9]. Available from: https://
www.goldcopd.org/
20. Mesquita R, Franssen FME, Houben-Wilke S, Uszko-Lencer
NHMK, Vanflerteren LEGW, et al. What is the impact of impaired
left ventricular ejection fraction in COPD after adjusting for
confounders? Int J Cardiol. 2016;225:365-70. doi: 10.1016/j.
ijcard.2016.10.016
21. Global Initiative for Asthma. Global Strategy for Asthma
Management and Prevention [Internet]. 2023 [updated 2023;
cited 2026 Mar 9]. Available from: http://www.ginasthma.org/
22. Ministério da Saúde (BR). Técnica de aferição da Pressão Arterial
(PA) [Internet]. Brasil: Ministério da Saúde ; [cited 2026 Mar 9].
Available from: https://linhasdecuidado.saude.gov.br/
portal/hipertensao-arterial-sistemica-(HAS)-no-adulto/
tecnica-afericao-pa
23. Mesquita R, Donária L, Genz IC, Pitta F, Probst VS. Respiratory
muscle strength during and after hospitalization for COPD
Exacerbation. Respir Care. 2013;58(12):2142-9. doi: 10.4187/
respcare.02393
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Vanessa Garcia de Lima, Chayenne Chylld César Lopes, Luan dos Santos Mendes Costa, Andrea Felinto Moura, Magno F. Formiga, Rafael Mesquita

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.