Journal of Applied Oral Science

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JAOS

Current Issue

Vol. 34 (2026)

Published: 2026-01-13

Review

From enemy to ally: an update for dental professionals on oral microbiome ecology and its systemic implications

Camila Pinho e Souza Coelho, Júlia Maria de Sousa Munduri, Jéssica Alexandra de Vasques Castro Oliveira, Maria Izabel Moreira, Jéssica Alves de Cena, Naile Dame-Teixeira

e20260384
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Original Articles

Factors associated with orofacial myofunctional condition in patients with temporomandibular disorder and somatosensory tinnitus

Gislaine Aparecida Folha, Nelma Ellen Zamberlan-Amorim, Carina Ferreira Pinheiro-Araujo, Luana Maria Ramos Mendes, Gesseany Joice Rodrigues dos Santos, Debora Bevilaqua-Grossi

e20250515
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The modulatory effect of oxygen -releasing gel versus 0.8% hyaluronic acid gel incorporated hydroxyapatite bone graft in the management of grade II mandibular furcation defects: a randomized clinical control trial

Pavitra Jayakumar, Sharmistha Vijay, Debopriya Chatterjee, Setu Mathur Mathur

e20260115
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Antigenemia and oral lesions in paracoccidioidomycosis: is there a correlation?

Tatiana Teixeira de Miranda, Eva Burger

e20250566
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Effects of an orabase gel containing Libidibia ferrea extract on induced periodontitis in rats

Larissa dos Santos Pessoa, Even Herlany Pereira Alves, Hávila Torres Araújo, Marcondes Cavalcante Santana Neto, Felipe Rodolfo Pereira da Silva, Paulo Roberto Carneiro Gomes, Ayslan Batista Barros, José Delano Barreto Marinho Filho, Ana Jersia Araújo, Daniel Fernando Pereira Vasconcelos

e20260608
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Microstructures and mechanical characteristics of primary teeth affected by regional odontodysplasia

Wenxian Jiang, Minjian Shen, Jian Wang, Mengyao Bian, Haiyan Zheng, Zihuai Zhou, Ying Shi, Zhifang Wu

e20250499
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Genetic variants of EBI3, tumor Epstein-Barr virus, and human cytomegalovirus status in HPV-negative oral cancer

Marko Simonovic, Ruzica Kozomara, Sasa Jovic, Gordana Velikic, Elizabeta Ristanovic, Nikoleta Djordjevski, Danijela Djuric-Petkovic, Srboljub Stosic, Gordana Supic

e20250492
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Biofilm formation of mixed Candida albicans and methicillin-sensitive Staphylococcus aureus and surface properties of a 3D-printed denture base resin under different printing parameters

Larianne S. Moisés, Hamile Emanuella do Carmo Viotto, Sabrina Romão Gonçalves Coelho, Danny Omar Mendoza Marin, Raphael Freitas Souza, Ana Carolina Pero

e20250526
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Comparison of root coverage by injectable-platelet rich fibrin in thick and thin phenotypes a parallel-armed, prospective, preliminary clinical study with up to 48 months of follow-up
Immunohistochemical analysis of phospho-ERK1/2 in odontogenic cysts

Nakarin Kitkumthorn, Jintana Pankam, Siribang-on Piboonniyom Khovidhunkit, Athittaya Phaephayom, Puangwan Lapthanasupkul
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A dual-scale micro/nanofibrous PLGA scaffold fabricated by co-electrospinning for regenerative endodontic procedures

Stephanie Isabel Diaz Zamalloa; Caroline Carvalho dos Santos, Leticia Martins Santos, Victor Elias Arana-Chavez, Fernando Neves Nogueira, Carla Renata Sipert, Celso Luiz Caldeira

e20260524
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Wavelength-dependent cytokine modulation in metabolically stressed fibroblasts

Samantha Bender, Sharanya Singh, Lauren Lamoutte, Mateus Garcia Rocha, Shannon M Wallet, Margarete Ribeiro da Silva, Dayane Oliveira
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Dynamics of oropharyngeal structures during respiration with the volume-altered tongue base of minipigs

Nino Geradze, Doris Haydee Rosero Salazar, Phuc Hoang Nguyen, Zi-Jun Liu

e2025-0722
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Bioactive luting cements on the adhesive interface of fiber post and root dentin a comparative study of bond strength, water interaction, and enzymatic degradation

Tiago Carvalho dos Santos, Giovanna Speranza Zabeu, Ana Carolina Almeida Lima, Mylena Proença Costa, Marcela Rocha Carrilho, Linda Wang

e20250576
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Expression of p53, Ki-67, sox-2, oct-4, and NANOG in the tongue and trachea of Swiss mice exposed to narghile smoke

Sarah Freygang Mendes Pilati, Filipe Ivan Daniel, Paulo Vinicius Fontanella Pilati, Mariana Hornung Marins, Aline Cristina Batista Rodrigues, Filipe Modolo

e2025-0839
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Can angiotensin II affect the inflammatory response of human dental pulp cells in vitro?

Bella Luna Colombini-Ishikiriama, Thiago José Dionisio, Thais Francini Garbieri, Rafaela Alves da Silva, Sandra Helena Penha Oliveira, Vanessa Soares Lara, Andrew Seth Greene, Carlos Ferreira dos Santos

e2025-0822
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Assessment of chitosan addition to at-home bleaching gel with and without calcium on the physical properties of tooth enamel

Laura Nobre Ferraz, Letícia de Souza Franco, Carolina Meneghin Barbosa, Marcos Roberto de Lima Benati, Tatiane Cristina Dotta, Waldemir Francisco Vieira-Junior, Débora Alves Nunes Leite Lima

e20250513
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Implant placement accuracy using computer-guided surgical templates supported by bone and mucosa: an in vitro study

Ana Maria Alves Ribeiro, Déborah Rocha Seixas, Eduardo Sanches Gonçalves

e20250926
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The effect of Stage I-II periodontitis on the mechanical, structural, and biological properties of leukocyte and platelet-rich fibrin

Sarvar Ibrahimli, Meltem Karsiyaka Hendek, Kubilay Baris, Ebru Olgun

E2025-0483
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Synergistic growth, metabolic products, and matrix quantification in dual-species biofilms of oral pathogens

Evelyn Giuliana Velásquez-Espedilla, Victor Feliz Pedrinha, Maricel Rosario Cardenas Cuellar, Pedro Luis Busto Rosim, Daniela Alejandra Cusicanqui Méndez, Thiago Cruvinel, Flaviana Bombarda de Andrade

e2025-0887
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Influence of impacted mandibular third molars on pathological changes on themselves and adjacent tissues across different age groups a cross-sectional study

Xiaoyue Ge, Yixiao Cui, Ning Li, Tianyang Lv, Yuntong Liang, Haochen Wu, Yuxuan Gu, Meiting Li, Changkui Liu, Yayuan Guo, Kaijin Hu

e20250677
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Cognitive and Orofacial Intersections prevalence of temporomandibular disorders and bruxism in individuals with symptoms of attention deficit hyperactivity disorder

Arthur Alexis Valentin Caron, Rodrigo Lorenz Poluha, Marlon Ferreira Dias, Dyanne Medina Flores, Alfonso Sanchéz-Ayala, Justin Durham, Giancarlo De la Torre Canales

e2025-0771
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Curcumin-loaded chitosan thermosensitive hydrogel with sustained release for periodontal applications: an in vitro evaluation

Reema M Rao, Monali Nikalje, Shiprita Kumari, Rahul Tiwari, Kailash Chandra Dash, Saurabh Shekhar, Manish Sharma

e20260308
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Potency of moderate-intensity exercise on caspase-8 and caspase-9 expression in a DMBA-induced oral epithelial dysplasia rat model

Anis Irmawati, Rasha Fatimah Abdullah, Retno Indrawati Roestamadji, Ira Arundina, Noor Faizah Balqis, Noeroel Widajati, Raed Labib

e20260438
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Shades of knowledge awareness among Brazilian dentists on non- and microinvasive approaches for tooth discoloration

Giovanni Aguirra Giovanni Aguirra, Karin Landmayer, Bruna de Oliveira Iatarola, Maria Paula Novaes Camargo Manna, Raquel Shimizu Mori, Flávia Pardo Salata Nahsan, Heitor Marques Honório, Luciana Fávaro Francisconi-dos-Rios

e20250589
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Polyphenol-functionalized silver nanoparticles promote differential remineralization and reinforcement of demineralized dentin

Tattiana Enrich, Santiago González-López, Alejandro B. Rodríguez-Navarro, María V. Bolaños-Carmona, Carolina Cifuentes-Jiménez

e20250848
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Association between serum vitamin D3 levels and gingival crevicular fluid osteocalcin and N-terminal telopeptide levels in periodontal health and disease

Burcin Cevik, Atanur Sarioglu, Tugrul Kirtiloglu, Bahattin Avci, Leman Tomak

e20260009
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Statin-loaded carbonated hydroxyapatite nanoemulsion controls matrix metalloproteinase-1 activity to enhance post-orthodontic stability in rats

Ananto Ali Alhasyimi, Niswati Fathmah Rosyida, Pinandi Sri Pudyani

e20260023
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Physicomechanical properties of PMMA denture base resins reinforced with nanofibers: a systematic review and meta-analysis

Bianca Tavares Rangel, Amanda Aparecida Maia Neves Garcia, Carolina Yoshi Campos Sugio, Vanessa Migliorini Urban, Simone Soares, Joel Ferreira Santiago Júnior, André Ulisses Dantas Batista, Karin Hermana Neppelenbroek

e20260076
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Expression of caspase-8 in non-alcoholic fatty liver disease related to ligature-induced periodontitis in rats

Felipe Rodolfo Pereira da Silva, Victor Brito Dantas Martins, Hélio Mateus Silva Nascimento, Paulo Roberto Carneiro Gomes, Nikaely Brandão Barbosa, Vinícius da Silva Caetano, Ivana Márcia Alves Diniz, Karine Duarte da Silva, Any Carolina Cardoso Guimarães Vasconcelos, Daniel Fernando Pereira Vasconcelos

e20250717
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Comparison of the effects of two different wound dressing materials on wound healing in mucosal defects created in diabetic and healthy rats

Merve Yalçın, Vildan Bostancı, Özhan Karataş

e20260096
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Comparative analysis of connective tissue graft versus ozone-enriched platelet-rich fibrin in the treatment of Cairo class I gingival recessions a randomized, double-blind, controlled clinical trial

Marina Pereira Silva, Maria Ritha Veiga Colognese, Carlos Augusto Nassar, Veridiana Camilotti

e20250565
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Self-adhesive flowable resin composite for occluso-proximal restorations in primary teeth: restorative time and fracture resistance analysis

Tyler Zanella Brustolin, Cleber Paradzinski Cavalheiro, Duvan Cala Castillo, Gabriel Kalil Rocha Pereira, Tathiane Larissa Lenzi

e20260045
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Impact of local hyaluronic acid on early gingival wound healing and heat shock protein 47

Gizem Ceren Yiğit, Feyza Otan Özden, Özgür Korhan Tunçel, Eser Çakmak, Fikret Yilmaz

e20260091
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Evaluation of bleaching efficacy and cytotoxicity of an experimental hydrogel containing MnO-Doped Biosilicate® activated by violet LED light

Rafael Dascanio, Rafael Antonio de Oliveira Ribeiro, Marina Trevelin Souza, Matheus Kury, Edgar Dutra Zanotto, Carlos Alberto de Souza Costa, Vanessa Cavalli

e20250503
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Hormone therapy and psychosocial factors in menopausal women with painful TMD: a pilot cross-sectional study

Lays Nóbrega Gomes Farias, Raimundo Euzébio da Costa Neto, Mayara Abreu Pinheiro, Yuri Wanderley Cavalcanti

e20250586
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Salivary cotinine and S100A8/A9 levels in children exposed to environmental tobacco smoke a case-control study

Arzu Kockanat, Sukran Acipinar

e20250840
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Bond strength in class V cavities: an in vitro study on beveling, universal adhesive strategy, and composite type

Felipe José Ribeiro de Melo, Viviane Rocha, Vivian Leite Martins, Marcos Vinícius Salvador, Adriano Fonseca Lima, Andrea Nóbrega Cavalcanti

e20250608
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SHED-exosomes functionalized micro-nano bioactive glass/PCL membrane regulates macrophage polarization and promotes osteogenic differentiation

Yongyong Yan, Haifeng Lan, Guohou Miao, Haiyan Wang, Zhengmao Li, Qing Zhang, Shuai Wang, Gang Wu, Richard T. Jaspers, Janak L. Pathak

e20250541
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Effects of live and heat-killed Bifidobacterium lactis in rats with induced periodontitis

Tainá da Silva Tricoly, Thais Aguiar Santos, Camila Lopes Ferreira, Itza Amarilis Ribeiro Pinto, Victoria Clara da Silva Lima, Camilla Magnoni Moretto Nunes, Ana Lia Anbinder, Maria Aparecida Neves Jardini

e2025-0634
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Osteogenic potential of mesenchymal stem cells derived from osteoporotic model cultured on microtextured titanium surfaces grades II, IV, and V

Rafael Almeida Rocha, Matheus Dias Polegati, Maria Vitória Barroso de Morais, Letícia Faustino Adolpho, Eduardo Henrique Backes, Gileade Pereira Freitas, Helena Bacha Lopes

e20260531
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Apical delta filling with calcium silicate and epoxy resin sealers using different obturation techniques by microcomputed tomography

Washington Soares dos Santos, Jefferson Augusto, Angelo José Sócrates Torres-Carrillo, Igor Bassi Ferreira Petean, Antonio Miranda da Cruz-Filho, Manoel Damião de Sousa-Neto, Fabiane Carneiro Lopes-Olhê, Jardel Francisco Mazzi-Chaves

e2025-0744
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The effect of physical activity on growth factor concentrations in platelet-rich fibrin: a cross-sectional study

Elif Yucel, Meltem Karsiyaka Hendek, Hakan Yapici, Mehmet Gulu, Osman Caglayan, Ebru Olgun

e20260128
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Application of machine learning techniques to automate speech mispronunciation detection in children and adolescents

Nazila Ameli, Mahshid Nik Ravesh, Luan Matheus Trindade Dalmazo, Karen Pollock, Daniel DeSantis, Manuel Lagravere, Hollis Lai

e20260078
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Parkinson's disease and Porphyromonas gingivalis levels a case-control study

Nathália Alves Gusmão, Augusto Paixão Moraes Mateus, Victor Bento Oliveira, Rafael Paschoal Esteves Lima, José Roberto Cortelli, Sheila Cavalca Cortelli, Fernando Oliveira Costa

e2025-0780
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Saliva liquid biopsy MMP2, MMP9, and TIMP2 as potential diagnostic biomarkers in oral squamous cell carcinoma. An observational case-control study

Sergio D. Cruz-Romero, Ana Margarita Baldión, José Antonio Hakim Tawil, Alberto Escallon, Paula A. Rodriguez-Urrego, Paula Alejandra Baldión

e20250555
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Histological findings in post-extraction sockets after alveolar ridge preservation with leukocyte- and platelet-rich fibrin: a randomized clinical trial

Maria Pavli, Maria Georgaki, Nadia Theologie-Lygidakis, Nikolaos Nikitakis, Christos Perisanidis

e20260283
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Evaluation of the early effects of peptide-containing agents in sensitivity treatment regarding their structural, morphological, and elemental changes in dentin tissue and their penetration efficacy

Tugba Ozdemir, Selcuk Savas, Ebru Kucukyilmaz Izgi

e20260127
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Effects of highly leukotoxic Aggregatibacter actinomycetemcomitans associated with ligature-induced periodontitis on oral and gut tissues in male rats

Gabriela Furian Trama Ferraz, Camila Philipe de Araujo Camilo, Ana Luisa Palhares de Miranda, Mariana Alves Soares, Carmelo Sansone, Ricardo Tadeu Lopes, Aline Correa Abrahão, Ana Paula Vieira Colombo, Carina Maciel Silva-Boghossian

e2025-0731
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Maqui berry cystatin inhibits cathepsin k activity and stimulates osteogenic differentiation of human dental pulp cells

Luana Raphael da Silva, Eduardo Pereira de, Bárbara Roma Mendes, Breno Henrique Amancio, Flávio Henrique-Silva, Gisele Faria

e20250661
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Clinical and aesthetic outcomes of enamel matrix derivative and subepithelial connective tissue graft using the modified coronally advanced tunnel technique a randomized controlled trial

Fatma Altiparmak, Fatma Ucan Yarkac

e2025-0775
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Risk Classification Instrument for Orofacial Myofunctional Disorders – ICR/DMO: Reliability (Part III)

Herick Santos Assis, Íkaro Daniel de Carvalho Barreto, Giédre Berretin-Felix, Andréa Monteiro Correia Medeiros

e20260314
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Comparison of root coverage by injectable-platelet rich fibrin in thick and thin phenotypes a parallel-armed, prospective, preliminary clinical study with up to 48 months of follow-up

Berceste Guler Ayyildiz, Busra Terzioglu, Seyma Eken

e20250702
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Notch2 is involved in regulating apical tissue repair following severe intrusive luxation

Yuanpei He, Xuyan Gong, Cancan Ding, Yang Qiu, Guangwen Li, Shiting Li

e20250490
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Hydrogel microarchitecture as a regulatory cue for in vitro odontogenic differentiation

Letícia Alves Martins de Carvalho, Vitor de Toledo Stuani, Isabela Sanches Pompeo da Berteli, Thayná Souza Berteli, Nicoly Gabriely Gonçalves, Diana Gabriela Soares, Ester Alves Ferreira Bordini

e2025-0607
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FOXO3a promotes odontoblast differentiation in human dental pulp cells in coordination with RUNX2

Su-Kyung Son, Jung-Sun Moon, Na-Ri Jung, Jee-Hae Kang, Bin-Na Lee, Min-Seok Kim

e20260114
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Association of periodontitis stages with glycemic control in adults with and without type 2 diabetes mellitus: a cross-sectional study

Maria Eduarda Oliveira Rodrigues, Josy Lorena Peres da Silva Vilarinho, João Gabriel Jucá Chermont, Cristine Miron Stefani, Valéria Martins de Araújo Carneiro, Maria do Carmo Machado Guimarães, Bruna Frizon Greggianin

e20260178
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Molecular alterations in MAPK/ERK, β-Catenin/Wnt, and PI3K/mTOR pathways in adenomatoid odontogenic tumor

Jintana Pankam, Puangwan Lapthanasupkul, Nakarin Kitkumthorn, Siribang-on Piboonniyom Khovidhunkit

e20260073
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Time-series trends and regional disparities in complete denture production in Brazil (2000–2023) an epidemiological analysis

Maria Eduarda Broering da Silva, Henrique Souza dos Santos, Juliana Silva Ribeiro de Andrade, Paulo Roberto Barbato, Maurício Malheiros Badaró

e20250779
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Diversity of Streptococcus mutans serotypes isolated from dental plaque of Brazilian patients with a history of acute myocardial infarction

Francisco Ruliglésio Rocha, Wanessa Fernandes Matias Regis, Rochelle Pinheiro Ribeiro, João Eudes Teixeira Pinho Filho, Tiago Lima Sampaio, Raquel Carvalho Montenegro, Ana Paula Negreiros Nunes Alves, Lidiany Karla Azevedo Rodrigues

e20250077
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Integrated analysis identifies CCNA2 as a candidate diagnostic and prognostic biomarker in oral tongue squamous cell carcinoma

Ceren Gumedag, Sevcan Atay

e20260618
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Hypodontia as an extended phenotype in families with nonsyndromic oral clefts: findings from a 39-family clinical cohort

Ana Laura Herrera Farha, Otávio Pagin, Izabel Maria Marchi de Carvalho, Ariadne Letra, Lucimara Teixeira das Neves

e20260193
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Modulation of TLR4, hBD-2, and hBD-3 expression and hepatic tissue response by systemic probiotics in experimental apical periodontitis in rats

Leopoldo Cosme-Silva, Renan Dal-Fabro, Gabrielle Cabral Melville de Souza Tenório, José Alex da Silva, Edilson Ervolino, Letícia Cabrera Copalbo, João Eduardo Gomes Filho

e20250859
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Amelogenin-derived peptide-5 suppresses the receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation via adenosine monophosphate-activated protein kinase activation

Hye-Yoon Koo, Suk-Gyun Park, Ju-Han Song, Jeong-Tae Koh, Sang-Hwa Park, Bin-Na Lee, Hoon-Sang Chang, In-Nam Hwang, Kkot-Byeol Bae, Yun-Chan Hwang

e20260347
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Effects of bromelain, melatonin, and thymoquinone on neutrophil extracellular trap formation and macrophage polarization in experimental periodontitis

Şükran Acipinar, Mustafa Ozkaraca, Ufuk Okkay, Ali Sefa Mendil

e20260699
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Lactobacillus sp. attenuates oral and hepatic alterations and decreases caspase-8 expression in ligature-induced periodontitis

Victor Lucas Ribeiro Lopes, Even Herlany Pereira Alves, Alan Leandro Farias de Carvalho, Vinícius da Silva Caetano, Hélio Mateus Silva Nascimento, Maria Vitoria Pereira de Sousa, Paulo Roberto Carneiro Gomes, Any Carolina Cardoso Guimarães Vasconcelos, André Luiz dos Reis Barbosa, Daniel Fernando Pereira Vasconcelos

e2026-0143
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DNA methyltransferases expressions in mice tongue exposed to waterpipe smoke

Carolina Simão Flausino, Sarah Freygang Mendes Pilati, Filipe Ivan Daniel, Filipe Modolo

e20250665
Zinc oxide and ellagic acid wound dressing enhances FGF-2 and VEGF expression during early excisional wound healing

Intan Nirwana, Ahmad Thariq Bermani, Yasmin Shahaniz, Ainira Fatya Ardialuna, Sulthan Raffi Aryaputra, Vianca Sashira Asmoro, Hasmaliza Mohamad, Anita Yuliati, Asti Meizarini

e20260544
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Physicomechanical and biological properties of additively manufactured photosensitive resins for provisional crowns using affordable LCD printer

Marina de Brito Teixeira, Marcelo Pereira Brod, Douver Michelon, Adriana Fernandes da Silva, Evandro Piva, Rafael Guerra Lund, Wellington Luiz de Oliveira da Rosa

e20260157
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Systemic toxicity assessment of tissue conditioners modified with nystatin and chlorhexidine in a rat model of denture stomatitis

Gustavo Simão Moraes, Thaís Albach, Carolina Yoshi Campos Sugio, Victoria Schlumberger Cachoeira, Falyne Kiratcz, Eduardo Bauml Campagnoli, Fabio André Dos Santos, Karin Hermana Neppelenbroek, Vanessa Migliorini Urban

e20250811
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Systematic Review

Prevalence and factors associated with pulp stones: a systematic review with meta-analysis and meta-regression

Yasmin Alves Sanches, Theodoro Weissheimer, Alex Nogueira Haas, Ricardo Abreu da Rosa, Gabriel Barcelos Só, Marcus Vinicius Reis Só

e20260252
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