Oral cancer stem cells - properties and consequences

Authors

  • Camila Oliveira Rodini Universidade de São Paulo; Faculdade de Odontologia de Bauru; Departamento de Ciências Biológicas
  • Nathália Martins Lopes Universidade de São Paulo; Faculdade de Odontologia de Bauru; Departamento de Ciências Biológicas
  • Vanessa Soares Lara Universidade de São Paulo; Faculdade de Odontologia de Bauru; Departamento de Cirurgia, Estomatologia, Patologia e Radiologia
  • Ian Campbell Mackenzie Queen Mary University of London; Blizard Institute - Barts and The London School of Medicine and Dentistry

DOI:

https://doi.org/10.1590/1678-7757-2016-0665

Keywords:

Neoplastic stem cells, Mouth neoplasms, Epithelial-mesenchymal transition, Neoplasm metastasis, Squamous cell carcinoma

Abstract

Research on cancer stem cells (CSCs) has greatly increased in the field of medicine and pathology; however, some conceptual misunderstandings are still present among the public as well as within the general scientific community that is not yet familiar with the subject. The very first problem is the misinterpretation of CSCs as a synonym of their normal counterparts, the well-known stem cells (SCs). Particularly in Dentistry, another common mistake is the misinterpretation of oral CSCs as normal tooth-derived SCs. The present review aims to clarify important concepts related to normal SCs and CSCs, as well as discuss the relevance of CSCs to the development, metastasis and therapy resistance of oral squamous cell carcinoma.

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Published

2017-12-01

Issue

Vol. 25 No. 6 (2017)

Section

Original Articles

License

Todo o conteúdo do periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons do tipo atribuição CC-BY.

 

 

How to Cite

Rodini, C. O., Lopes, N. M., Lara, V. S., & Mackenzie, I. C. (2017). Oral cancer stem cells - properties and consequences. Journal of Applied Oral Science, 25(6), 708-715. https://doi.org/10.1590/1678-7757-2016-0665