Preemptive analgesia with ibuprofen increases anesthetic efficacy in children with severe molar hypomineralization

a triple-blind randomized clinical trial

Authors

  • Fernanda Vicioni-Marques Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto, Departamento de Odontopediatria, Ribeirão Preto, São Paulo, Brasil. http://orcid.org/0000-0003-1741-3365
  • Francisco Wanderley Garcia de Paula-Silva Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto, Departamento de Odontopediatria, Ribeirão Preto, São Paulo, Brasil. http://orcid.org/0000-0001-8559-532X
  • Milena Rodrigues Carvalho Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto, Departamento de Odontopediatria, Ribeirão Preto, São Paulo, Brasil. http://orcid.org/0000-0002-5511-6073
  • Alexandra Mussolino de Queiroz Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto, Departamento de Odontopediatria, Ribeirão Preto, São Paulo, Brasil. http://orcid.org/0000-0003-2900-5000
  • Osvaldo de Freitas Universidade de São Paulo, Ribeirão Preto, Escola de Ciências Farmacêuticas de Ribeirão Preto São Paulo, Departamento de Ciências Farmacêuticas, Brasil. http://orcid.org/0000-0001-7055-2028
  • Maíra Peres Ferreira Duarte Universidade de São Paulo, Ribeirão Preto, Escola de Ciências Farmacêuticas de Ribeirão Preto São Paulo, Departamento de Ciências Farmacêuticas, Brasil. http://orcid.org/0000-0002-0385-6416
  • David John Manton University of Groningen, Faculty of Medical Sciences, Centrum voor Tandheelkunde en Mondzorgkunde, UMCG, The Netherlands. http://orcid.org/0000-0002-4570-0620
  • Fabrício Kitazono de Carvalho Universidade de São Paulo, Ribeirão Preto, Escola de Ciências Farmacêuticas de Ribeirão Preto São Paulo, Departamento de Ciências Farmacêuticas, Brasil. http://orcid.org/0000-0002-4837-0583

DOI:

https://doi.org/10.1590/1678-7757-2021-0538

Keywords:

Molar incisor hypomineralization, Preemptive analgesia, Tooth sensitivity, Dental enamel

Abstract

Molar incisor hypomineralization (MIH) is often accompanied by dental hypersensitivity and difficulty in achieving effective analgesia. Objective:
This study evaluated the effectiveness of preemptive analgesia in children with severe MIH, post-eruptive enamel breakdown, and hypersensitivity. Methodology: Ibuprofen (10 mg/kg child weight) or placebo was administered, followed by infiltrative anesthesia and restoration with resin composite. Hypersensitivity was evaluated in five moments. The data were analyzed using the chi-square test, Fisher’s exact test, and t-test. Results: Preemptive analgesia provided benefits for the treatment of severe cases of MIH, with an increase in the effectiveness of infiltrative anesthesia and improved patient comfort during the restorative procedure. Conclusion: Preemptive analgesia has shown efficacy in reducing hypersensitivity during restorative dental procedures, evidencing the significance of this study for patients with MIH and hypersensitivity.

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Published

2022-05-16

Issue

Vol. 30 (2022)

Section

Original Articles

License

Copyright (c) 2022 Journal of Applied Oral Science

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How to Cite

Vicioni-Marques, F., Paula-Silva, F. W. G. de, Carvalho, M. R., Queiroz, A. M. de, Freitas, O. de, Duarte, M. P. F., Manton, D. J., & Carvalho, F. K. de. (2022). Preemptive analgesia with ibuprofen increases anesthetic efficacy in children with severe molar hypomineralization: a triple-blind randomized clinical trial. Journal of Applied Oral Science, 30. https://doi.org/10.1590/1678-7757-2021-0538