Effect of avocado/soybean unsaponifiables on periodontal repair in rats with arthritis and induced periodontitis

Authors

  • Jackeline do Nascimento Tsurumaki Universidade Estadual Paulista (UNESP), Faculdade de Odontologia de Araraquara, Departamento de Diagnóstico e Cirurgia, Araraquara, São Paulo
  • Luiz Guilherme Freitas de Paula Centro Universitário de Anápolis, Faculdade de Odontologia (Unievangélica), Anápolis, Goiás
  • Sabrina Garcia de Aquino Universidade Federal da Paraíba, Faculdade de Odontologia, Departamento de Ciências da Saúde, João Pessoa, Paraíba http://orcid.org/0000-0002-3988-1939
  • Elcio Marcantonio Júnior Universidade Estadual Paulista (UNESP), Faculdade de Odontologia de Araraquara, Departamento de Diagnóstico e Cirurgia, Araraquara, São Paulo http://orcid.org/0000-0003-1294-2305
  • Guilherme José Pimentel Lopes de Oliveira Universidade Federal de Uberlândia, Faculdade de Odontologia, Departamento de Periodontia, Uberlândia, Minas Gerais http://orcid.org/0000-0001-8778-0115
  • Rosemary Adriana Chiérici Marcantonio Universidade Estadual Paulista (UNESP), Faculdade de Odontologia de Araraquara, Departamento de Diagnóstico e Cirurgia, Araraquara, São Paulo http://orcid.org/0000-0002-5052-7439

DOI:

https://doi.org/10.1590/1678-7757-2018-0602

Keywords:

Arthritis, Bone regeneration, Drug therapy, Periodontitis

Abstract

Objective: This study aimed to evaluate the effect of avocado/soybean unsaponifiables (ASU) on periodontal repair in rats with induced periodontitis and arthritis. Methodology: Forty-five rats were submitted to periodontitis induction by insertion of ligatures into the upper second molars, maintained for 15 days. These animals were randomly allocated to 3 groups according to the presence of induced arthritis (ART) and the application of the ASU: Control (CTR) group-healthy animals, where saline solution was administered; ART-animals with induced arthritis, where saline solution was administered; ART/ASU-animals with induced arthritis, where ASU (0.6 mg/ kg) was administered. The drugs were administered daily by gavage and the animals were euthanized after 7, 15 and 30 days of the ligature removal. Bone resorption, inflammatory infiltrate composition and marker proteins expression of the differentiation and formation of osteoclasts (RANKL and TRAP) were assessed. Results: The ART/ASU group presented higher bone volume than the ART group at 7 and 30 days after the ligature removal. Furthermore, the ART group presented higher quantity of inflammatory cells and expression of TRAP and RANKL than the other groups. Conclusion: ASU administration improves the repair of periodontal tissues in an experimental periodontitis model in rats with induced arthritis.

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Published

2022-08-02

Issue

Vol. 27 (2019)

Section

Original Articles

License

Copyright (c) 2022 Journal of Applied Oral Science

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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How to Cite

Tsurumaki, J. do N., Paula, L. G. F. de, Aquino, S. G. de, Marcantonio Júnior, E., Oliveira, G. J. P. L. de, & Marcantonio, R. A. C. (2022). Effect of avocado/soybean unsaponifiables on periodontal repair in rats with arthritis and induced periodontitis. Journal of Applied Oral Science, 27, e20180602. https://doi.org/10.1590/1678-7757-2018-0602