Osteoradionecrosis of the jaws: case series treated with adjuvant low-level laser therapy and antimicrobial photodynamic therapy

Authors

  • Guilherme Henrique Ribeiro Universidade Federal de Santa Catarina, Núcleo de Odontologia Hospitalar do Hospital Universitário, Florianópolis, SC
  • Mariana Comparotto Minamisako Serviço de Odontologia do Centro de Pesquisas Oncológicas de Santa Catarina, Florianópolis, SC
  • Inês Beatriz da Silva Rath Universidade Federal de Santa Catarina, Núcleo de Odontologia Hospitalar do Hospital Universitário, Florianópolis, SC
  • Alyne Simões Universidade de São Paulo, Departamento de Biomateriais e Biologia Oral, São Paulo, SP
  • Keila Cristina Rausch Pereira Universidade do Sul de Santa Catarina, Departamento de Odontologia, Palhoça, SC
  • Liliane Janete Grando Universidade Federal de Santa Catarina, Núcleo de Odontologia Hospitalar do Hospital Universitário, Florianópolis, SC https://orcid.org/0000-0002-6876-1151

DOI:

https://doi.org/10.1590/1678-7757-2017-0172

Keywords:

Osteoradionecrosis, Oral cancer, Radiotherapy, Low-level laser therapy, Antimicrobial photodynamic therapy

Abstract

Background: Osteoradionecrosis of the jaw (ORNJ) is the most severe and complex sequel of head and neck radiotherapy (RT) because of the bone involved, it may cause pain, paresthesia, foul odor, fistulae with suppuration, need for extra oral communication and pathological fracture. We treated twenty lesions of ORNJ using low-level laser therapy (LLLT) and antimicrobial photodynamic therapy (aPDT). The objective of this study was to stimulate the affected area to homeostasis and to promote the healing of the oral mucosa. Methods: We performed aPDT on the exposed bone, while LLLT was performed around the bone exposure (red spectrum) and on the affected jaw (infrared spectrum). Monitoring and clinical intervention occurred weekly or biweekly for 2 years. Results: 100% of the sample presented clinical improvement, and 80% presented complete covering of the bone exposure by intact oral mucosa. Conclusion:
LLLT and aPDT showed positive results as an adjuvant therapy to treat ORNJ.

Downloads

Downloads

Published

2022-08-31 — Updated on 2022-08-31

Versions

Issue

Vol. 26 (2018)

Section

Original Articles

License

Copyright (c) 2022 Journal of Applied Oral Science

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Todo o conteúdo do periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons do tipo atribuição CC-BY.

 

 

How to Cite

Ribeiro, G. H., Minamisako, M. C., Rath, I. B. da S., Simões, A., Pereira, K. C. R., & Grando, L. J. (2022). Osteoradionecrosis of the jaws: case series treated with adjuvant low-level laser therapy and antimicrobial photodynamic therapy. Journal of Applied Oral Science, 26, e20170172. https://doi.org/10.1590/1678-7757-2017-0172