Nasopalatine duct cyst: a multicenter retrospective study of 63 cases and an integrative review of the clinical, imaginological and histopathological aspects

Authors

  • Diana Estefania Ramos Peña Universidade de São Paulo. Faculdade de Odontologia, São Paulo, São Paulo https://orcid.org/0000-0003-4880-4780
  • Mariana de Sá Alves Universidade Estadual Paulista (UNESP). Instituto de Ciência e Tecnologia, Campus de São José dos Campos, São José dos Campos, São Paulo https://orcid.org/0000-0002-0956-0747
  • Samuel Porfírio Xavier Universidade de São Paulo. Faculdade de Odontologia de Ribeirão Preto, Ribeirão Preto https://orcid.org/0000-0001-7389-5886
  • Tiago Novaes Pinheiro Universidade do Estado do Amazonas, Divisão de Estomatologia e Patologia Oral, Manaus, Amazonas https://orcid.org/0000-0003-2987-4759
  • Paulo Sérgio da Silva Santos Universidade de São Paulo. Faculdade de Odontologia de Bauru, Bauru, São Paulo https://orcid.org/0000-0002-0674-3759
  • Izabel Regina Fischer Rubira-Bullen Universidade de São Paulo. Faculdade de Odontologia de Bauru, Estomatologia, Patologia e Radiologia, Bauru, São Paulo https://orcid.org/0000-0002-5069-9433
  • Ana María Cadavid Giraldo Universidad de Antioquia. Facultad de Odontología, Grupo de investigación en Patología Oral, Periodoncia y Cirurgía-Alveólo-Dentaria – POPCAD, Medellín https://orcid.org/0000-0001-5697-0100
  • Pilar Schmitt Sanjuan Navarro Universidad de Antioquia. Facultad de Odontología, Grupo de investigación en Patología Oral, Periodoncia y Cirurgía-Alveólo-Dentaria – POPCAD, Medellín
  • Leonor Victoria González-Pérez Universidad de Antioquia. Facultad de Odontología, Grupo de investigación en Patología Oral, Periodoncia y Cirurgía-Alveólo-Dentaria – POPCAD, Medellín https://orcid.org/0000-0002-2729-7495
  • Cintia Micaela Chamorro Petranacci Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes). Faculty of Medicine and Dentistry Universidade de Santiago de Compostela, Santiago de Compostela
  • Mario Perez-Sayáns Oral Medicine. Oral Surgery and Implantology Unit (MedOralRes). Faculty of Medicine and Dentistry Universidade de Santiago de Compostela, Santiago de Compostela https://orcid.org/0000-0003-2196-9868
  • Ana Lia Anbinder Universidade Estadual Paulista (UNESP), Instituto de Ciência e Tecnologia, Campus de São José dos Campos, São José dos Campos, São Paulo https://orcid.org/0000-0003-3930-4274
  • Janete Dias Almeida Universidade Estadual Paulista (UNESP). Instituto de Ciência e Tecnologia, Campus de São José dos Campos, São José dos Campos, São Paulo
  • Ana Carolina Fragoso Motta Universidade de São Paulo. Faculdade de Odontologia de Ribeirão Preto, Saúde Coletiva e Odontologia Legal, Ribeirão Preto https://orcid.org/0000-0002-3887-9239

DOI:

https://doi.org/10.1590/1678-7757-2024-0539

Keywords:

Nonodontogenic cysts, Diagnostic imaging, Oral Pathology, Oral diagnosis, Multicenter Study

Abstract

The nasopalatine duct cyst (NPDC) is the most common nonodontogenic jaw cyst, with a higher prevalence reported in males. Diagnosing jaw cysts remains challenging for general dentists due to their overlapping clinical and radiographic presentations. An updated case series and integrative literature review may assist in improving the accurate diagnosis of NPDC. Objective  This study aimed to describe the clinicopathological and imaging characteristics of 63 NPDC cases and to review previously reported cases in the literature. Methodology  An international, multicenter, retrospective NPDC case series was conducted. Demographic, radiographic, and histopathological data were collected from clinical records. Additionally, a PubMed/MEDLINE search was performed to identify articles on NPDC. Results  A total of 63 NPDC cases were evaluated, with a mean patient age of 47 years and no significant sex predilection. Twenty-one cases were asymptomatic, while 34 presented with symptoms such as pain and swelling. Radiographically, NPDC appeared as a well-defined radiolucent lesion located between the upper central incisors, bordered by a radiopaque margin. The integrative literature review identified 67 studies, comprising 51 case reports, 12 retrospective studies, and four case series, totaling 1,003 reported NPDC cases. The clinicopathological and radiographic findings from the literature aligned with those in this case series. Conclusion  The 63 cases analyzed in this study showed consistent findings across six international centers, with no sex predilection observed, contrasting with the male dominance reported in the literature. NPDC should be considered in the differential diagnosis of intraosseous lesions in the anterior maxilla. Accurate diagnosis requires a combination of radiographic and histopathological evaluations to prevent misdiagnosis and improper treatment. 

Downloads

Download data is not yet available.

References

Meyer AW. A unique supernumerary paranasal sinus directly above the incisors. J Anat. 1914;48:118-29.

Grossmann SM, Machado VC, Xavier GM, Moura MD, Gomez RS, Aguiar MC, et al. Demographic profile of odontogenic and selected nonodontogenic cysts in a Brazilian population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104(6):e35-41. doi: 10.1016/j.tripleo.2007.05.028. »https://doi.org/10.1016/j.tripleo.2007.05.028.

Nonaka CF, Henriques ÁC, Matos FR, Souza LB, Pinto LP. Nonodontogenic cysts of the oral and maxillofacial region: demographic profile in a Brazilian population over a 40-year period. Eur Arch Otorhinolaryngol. 2011;268(6):917-22. doi: 10.1007/s00405-010-1458-x

»https://doi.org/10.1007/s00405-010-1458-x.

WHO. WHO Classification of tumours editorial board. Head and neck tumours. 5th ed. Lyon (France); 2022.

Anneroth G, Hall G, Stuge U. Nasopalatine duct cyst. Int J Oral Maxillofac Surg. 1986;15(5):572-80. doi: 10.1016/s0300-9785(86)80061-8

»https://doi.org/10.1016/s0300-9785(86)80061-8.

Abrams AM, Howell FV, Bullock WK. Nasopalatine cysts. Oral Surg Oral Med Oral Pathol. 1963;16(3):306-32. doi: 10.1016/0030-4220(63)90295-0. »https://doi.org/10.1016/0030-4220(63)90295-0.

Allard RH, Van Der Kwast WA, Van der Waal I. Nasopalatine duct cyst: review of the literature and report of 22 cases. Int J Oral Surg. 1981;10(6):447-61. doi: 10.1016/s0300-9785(81)80081-6. »https://doi.org/10.1016/s0300-9785(81)80081-6.

Suter VG, Büttner M, Altermatt HJ, Reichart PA, Bornstein MM. Expansive nasopalatine duct cysts with nasal involvement mimicking apical lesions of endodontic origin: a report of two cases. J Endod. 2011;37(9):1320-6. doi: 10.1016/j.joen.2011.05.041.

»https://doi.org/10.1016/j.joen.2011.05.041.

Vasconcelos R, Aguiar MF, Castro W, Araújo VC, Mesquita R. Retrospective analysis of 31 cases of nasopalatine duct cyst. Oral Dis. 1999;5(4):325-8. doi: 10.1111/j.1601-0825.1999.tb00098.x. »https://doi.org/10.1111/j.1601-0825.1999.tb00098.x.

Suter VG, Sendi P, Reichart PA, Bornstein MM. The nasopalatine duct cyst: an analysis of the relation between clinical symptoms, cyst dimensions, and involvement of neighboring anatomical structures using cone beam computed tomography. J Oral Maxillofac Surg. 2011;69(10):2595-603. doi: 10.1016/j.joms.2010.11.032. »https://doi.org/10.1016/j.joms.2010.11.032.

Hilfer PB, Bergeron BE, Ozgul ES, Wong DK. Misdiagnosis of a nasopalatine duct cyst: a case report. J Endod. 2013;39(9):1185-8. doi: 10.1016/j.joen.2013.04.033. »https://doi.org/10.1016/j.joen.2013.04.033.

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372(71). doi: 10.1136/bmj.n71. »https://doi.org/10.1136/bmj.n71.

Aparna M, Chakravarthy A, Acharya SR, Radhakrishnan R. A clinical report demonstrating the significance of distinguishing a nasopalatine duct cyst from a radicular cyst. BMJ Case Rep. 2014;2014:bcr2013200329. doi: 10.1136/bcr-2013-200329. »https://doi.org/10.1136/bcr-2013-200329.

McCrea SJ. Nasopalatine duct cyst, a delayed complication to successful dental implant placement: diagnosis and surgical management. J Oral Implantol. 2014;40(2):189-94. doi: 10.1563/AAID-JOI-D-12-00011. »https://doi.org/10.1563/AAID-JOI-D-12-00011.

Escoda Francolí J, Almendros Marqués N, Berini Aytés L, Gay Escoda C. Nasopalatine duct cyst: report of 22 cases and review of the literature. Med Oral Patol Oral Cir Bucal. 2008;13(7):e438-43.

Elliott KA, Franzese CB, Pitman KT. Diagnosis and surgical management of nasopalatine duct cysts. Laryngoscope. 2004;114(8):1336-40. doi: 10.1097/00005537-200408000-00004. »https://doi.org/10.1097/00005537-200408000-00004.

Tanaka S, Iida S, Murakami S, Kishino M, Yamada C, Okura M. Extensive nasopalatine duct cyst causing nasolabial protrusion. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106(4):e46-50. doi: 10.1016/j.tripleo.2008.05.046. »https://doi.org/10.1016/j.tripleo.2008.05.046.

Perumal CJ. An unusually large destructive nasopalatine duct cyst: a case report. J Maxillofac Oral Surg. 2013;12(1):100-4. doi: 10.1007/s12663-011-0201-5. »https://doi.org/10.1007/s12663-011-0201-5.

Wu PW, Lee TJ, Huang CC, Huang CC. Transnasal endoscopic marsupialization for a huge nasopalatine duct cyst with nasal involvement. J Oral Maxillofac Surg. 2013;71(5):891-3. doi: 10.1016/j.joms.2012.11.002. »https://doi.org/10.1016/j.joms.2012.11.002.

Kang JW, Kim HJ, Nam W, Kim CH. Endoscopic endonasal marsupialization of nasopalatine duct cyst. J Craniofac Surg. 2014;25(2):e155-6. doi: 10.1097/SCS.0000000000000417. »https://doi.org/10.1097/SCS.0000000000000417.

Sane VD, Gadre KS, Halli R, Singh V, Doshi P, Saddiwal R, et al. Role of cone-beam computed tomography in diagnosis and management of nasopalatine duct cyst. J Craniofac Surg. 2014;25(1):e92-4. doi: 10.1097/SCS.0000000000000427. »https://doi.org/10.1097/SCS.0000000000000427.

Honkura Y, Nomura K, Oshima H, Takata Y, Hidaka H, Katori Y. Bilateral endoscopic endonasal marsupialization of nasopalatine duct cyst. Clin Pract. 2015;5(1):20-2. doi: 10.4081/cp.2015.748. »https://doi.org/10.4081/cp.2015.748.

Sankar D, Muthusubramanian V, Nathan J, Nutalapati R, Jose Y, Kumar Yn. Aggressive nasopalatine duct cyst with complete destruction of palatine bone. J Pharm Bioallied Sci. 2016;8(Suppl 1):s185-8. doi: 10.4103/0975-7406.191956. »https://doi.org/10.4103/0975-7406.191956.

Hasan S, Popli DB, Ahmad SA, Sircar K, Mansoori S, Dua K. Nasopalatine duct cyst with impacted inverted mesiodens: a rare case report and literature review. Case Rep Dent. 2022;2022:2022:5981020. doi: 10.1155/2022/5981020 1-10. »https://doi.org/10.1155/2022/5981020.

Alassaf MS, Abu Aof MM, Othman A, Zaki H, Almutairi AG. Coexistence of a nasopalatine duct cyst and radicular cyst: a unique clinical presentation. Cureus. 2023;15(10):e46774. doi: 10.7759/cureus.46774. »https://doi.org/10.7759/cureus.46774.

Kim SJ, Moon JW, Lee HM. Huge nasopalatine duct cyst treated by transnasal endoscopic marsupialization: a case report and literature review. Ear Nose Throat J. 2023;14556132311779. doi: 10.1177/01455613231177986. »https://doi.org/10.1177/01455613231177986.

Talebi Ardakani M, Houshmand B, Kheiri A. Nasopalatine duct cyst as a delayed consequence of dental implant placement in the anterior maxilla: a case report. J Adv Periodontol Implant Dent. 2023;15(2):134-7. doi: 10.34172/japid.2023.022. »https://doi.org/10.34172/japid.2023.022.

Khalil A, Albash Z. Large nasopalatine duct cyst in a child patient: a case report. Ann Med Surg (Lond). 2024;86(7):4280-3. doi: 10.1097/MS9.0000000000002224. »https://doi.org/10.1097/MS9.0000000000002224.

Srikanth G, Krishnan R, Malladi UK, Shetty N, Carnelio S, Shukla AD. Nasopalatine duct cyst associated with non-vital teeth: report of a rare case. Indian J Otolaryngol Head Neck Surg. 2024;76(3):2761-4. doi: 10.1007/s12070-024-04513-1. »https://doi.org/10.1007/s12070-024-04513-1.

Sheikh O, Hussein A, Mukhtar A, Abdi I, Ahmed N, Mohamed S. Nasopalatine duct cyst treated by transnasal endoscopic marsupialization: a case report. Int Med Case Rep J. 2024;17:459-64. doi: 10.2147/IMCRJ.S443199. »https://doi.org/10.2147/IMCRJ.S443199.

Gopal D, Telang A, Telang LA, Loganathan K, Reddy BT. Nasopalatine duct cyst associated with a mesiodens: misdiagnosis or missed diagnosis? J Clin Diagn Res. 2015;9(5):ZD21-2. doi: 10.7860/JCDR/2015/12604.5915. »https://doi.org/10.7860/JCDR/2015/12604.5915.

Hertzanu Y, Cohen M, Mendelsohn DB. Nasopalatine duct cyst. Clin Radiol. 1985;36(2):153-8. doi: 10.1016/s0009-9260(85)80099-4

»https://doi.org/10.1016/s0009-9260(85)80099-4.

Levy DH, Dinur N, Becker T, Azizi H, Ben Itzhak J, Solomonov M. Use of cone-beam computed tomography as a critical component in the diagnosis of an infected nasopalatine duct cyst mimicking chronic apical abscess: a case report. J Endod. 2021;47(7):1177-81. doi: 10.1016/j.joen.2021.04.018. »https://doi.org/10.1016/j.joen.2021.04.018.

Casado PL, Donner M, Pascarelli B, Derocy C, Duarte ME, Barboza EP. Immediate dental implant failure associated with nasopalatine duct cyst. Implant Dent. 2008;17(2):169-75. doi: 10.1097/ID.0b013e3181776c52. »https://doi.org/10.1097/ID.0b013e3181776c52.

Gao X, Dai S, Yan X, Jia X, Huang B, Zhang H, et al. Successful treatment of nasopalatine duct cyst after maxillary anterior implant surgery: a case report. J Oral Implantol. 2024;50(5):492-8. doi: 10.1563/aaid-joi-D-23-00052. »https://doi.org/10.1563/aaid-joi-D-23-00052.

Nortjé CJ, Farman AG. Nasopalatine duct cyst. An aggressive condition in adolescent Negroes from South Africa? Int J Oral Surg. 1978;7(2):65-72. doi: 10.1016/s0300-9785(78)80049-0. »https://doi.org/10.1016/s0300-9785(78)80049-0.

Schott TR, Correli RW, Wescott WB. Well-defined radiolucent area involving the anterior maxilla. J Am Dent Assoc. 1985;110(1):86-8. doi: 10.14219/jada.archive.1985.0310. »https://doi.org/10.14219/jada.archive.1985.0310.

Bodin I, Isacsson G, Julin P. Cysts of the nasopalatine duct. Int J Oral Maxillofac Surg. 1986;15(6):696-706. doi: 10.1016/s0300-9785(86)80110-7. »https://doi.org/10.1016/s0300-9785(86)80110-7.

Brown FH, Houston GD, Lubow RM, Sagan MA. Cyst of the Incisive (palatine) Papilla. J Periodontol. 1987;58(4):274-5. doi: 10.1902/jop.1987.58.4.274. »https://doi.org/10.1902/jop.1987.58.4.274.

Swanson KS, Kaugars GE, Gunsolley JC. Nasopalatine duct cyst: an analysis of 334 cases. J Oral Maxillofac Surg. 1991;49(3):268-71. doi: 10.1016/0278-2391(91)90217-a. »https://doi.org/10.1016/0278-2391(91)90217-a.

Velasquez-Smith MT, Mason C, Coonar H, Bennett J. A nasopalatine cyst in an 8-year-old child. Int J Paediatr Dent. 2001;9(2):123-7. doi: 10.1046/j.1365-263x.1999.00114.x. »https://doi.org/10.1046/j.1365-263x.1999.00114.x.

Righini CA, Bettega G, Boubagra K, Reyt E. Nasopalatine duct cyst (NPDc): one case report. Acta Otorhinolaryngol Belg. 2004;58(2):129-33.

Scolozzi P, Martinez A, Richter M, Lombardi T. A nasopalatine duct cyst in a 7-year-old child. Pediatr Dent. 2008;30(6):530-4.

Cicciù M, Battista Grossi G, Borgonovo A, Santoro G, Pallotti F, Maiorana C. Rare bilateral nasopalatine duct cysts: a case report. Open Dent J. 2010;4(1):8-12. doi: 10.2174/1874210601004010008. »https://doi.org/10.2174/1874210601004010008.

Shylaja S, Balaji K, Krishna A. Nasopalatine duct cyst: report of a case with review of literature. Indian J Otolaryngol Head Neck Surg. 2013;65(4):385-8. doi: 10.1007/s12070-011-0242-6. »https://doi.org/10.1007/s12070-011-0242-6.

Aldelaimi TN, Khalil AA. Diagnosis and surgical management of nasopalatine duct cysts. J Craniofac Surg. 2012;23(5):e472-4. doi: 10.1097/SCS.0b013e318258764b. »https://doi.org/10.1097/SCS.0b013e318258764b.

Cecchetti F, Ottria L, Bartuli F, Bramanti NE, Arcuri C. Prevalence, distribution, and differential diagnosis of nasopalatine duct cysts. Oral Implantol (Rome). 2012;5(2-3):47-53.

Dedhia P, Dedhia S, Dhokar A, Desai A. Nasopalatine duct cyst. Case Rep Dent. 2013;2013 2013:869516. doi: 10.1155/2013/869516.

»https://doi.org/10.1155/2013/869516.

Suter VG, Warnakulasuriya S, Reichart PA, Bornstein MM. Radiographic volume analysis as a novel tool to determine nasopalatine duct cyst dimensions and its association with presenting symptoms and postoperative complications. Clin Oral Investig. 2015;19(7):1611-8. doi: 10.1007/s00784-014-1391-2. »https://doi.org/10.1007/s00784-014-1391-2.

Cavalcante IL, Barros CC, Cunha JL, Cruz VM, Pedrosa GA, Santos Ad, et al. Clinicopathologic features of nasopalatine duct cysts: a retrospective study in two Brazilian oral and maxillofacial pathology referral centers. Med Oral Patol Oral Cir Bucal. 2021;26(5):e676-83. doi: 10.4317/medoral.24718. »https://doi.org/10.4317/medoral.24718.

Al-Haj Husain A, Schönegg D, Valdec S, Stadlinger B, Piccirelli M, Winklhofer S. Appearance of nasopalatine duct cysts on dental magnetic resonance imaging using a mandibular coil: two case reports with a literature review. Imaging Sci Dent. 2023;53(2):161-8. doi: 10.5624/isd.20220215. »https://doi.org/10.5624/isd.20220215.

Chen IJ, Lai PT, Jin YT, Chiang CP. Nasopalatine duct cyst - diagnosis from the content in the cystic wall. J Dent Sci. 2023;18(3):1449-51. doi: 10.1016/j.jds.2023.05.012. »https://doi.org/10.1016/j.jds.2023.05.012.

Lee YP, Hwang MJ, Jin YT, Chiang CP. Nasopalatine duct cyst: characteristic histopathological features. J Dent Sci. 2024;19(2):1216-8. doi: 10.1016/j.jds.2024.02.010. »https://doi.org/10.1016/j.jds.2024.02.010.

Hegde R, Shetty R. Nasopalatine duct cyst. J Indian Soc Pedod Prev Dent. 2006;24(Suppl 1):31-2.

Staretz LR, Brada BJ, Schott TR. Well-defined radiolucent lesion in the maxillary anterior region. J Am Dent Assoc. 1990;120(3):335-6. doi: 10.14219/jada.archive.1990.0061. »https://doi.org/10.14219/jada.archive.1990.0061.

Ely N, Sheehy EC, McDonald F. Nasopalatine duct cyst: a case report. Int J Paediatr Dent. 2008;11(2):135-7. doi: 10.1046/j.1365-263x.2001.00248.x. »https://doi.org/10.1046/j.1365-263x.2001.00248.x.

Khan M, Robia Ghafoor, Siddiqui HK. Nasopalatine canal cyst, a diagnostic twist. J Pak Med Assoc. 2024;74(4):811-4. doi: 10.47391/JPMA.9934. »https://doi.org/10.47391/JPMA.9934.

Kagoya R, Iwanami T, Mochizuki M, Kondo K, Ito K. Case report: unilateral transnasal endoscopic marsupialization of nasopalatine duct cyst. Front Surg. 2022;9:978915. doi: 10.3389/fsurg.2022.978915. »https://doi.org/10.3389/fsurg.2022.978915.

Faitaroni LA, Bueno MR, Carvalhosa AA, Mendona EF, Estrela C. Differential diagnosis of apical periodontitis and nasopalatine duct cyst. J Endod. 2011;37(3):403-10. doi: 10.1016/j.joen.2010.11.022. »https://doi.org/10.1016/j.joen.2010.11.022.

Fujioka-Kobayashi M, Miyasaka N, Miyasaka A, Koyanagi M, Inada R, Miyasaka T, et al. A custom-made surgical guide for accurate enucleation of nasopalatine duct cysts: a technical note and case report. Case Rep Dent. 2023;2023:1-5. doi: 10.1155/2023/9246701.

»https://doi.org/10.1155/2023/9246701.

Torres LM, Benito JI, Morais D, Fernández A. Quiste del conducto nasopalatino: a propósito de un caso [Nasopalatine duct cyst: case report]. Acta Otorrinolaringol Esp. 2008 May;59(5):250-1. Spanish.

Nelson BL, Linfesty RL. Nasopalatine duct cyst. Head Neck Pathol. 2010;4(2):121-2. doi: 10.1007/s12105-010-0169-3. »https://doi.org/10.1007/s12105-010-0169-3.

Mesquita JA, Luna AH, Nonaka CF, Godoy GP, Alves PM. Clinical, tomographic and histopathological aspects of the nasopalatine duct cyst. Braz J Otorhinolaryngol. 2014;80(5):448-50. doi: 10.1016/j.bjorl.2014.05.020. »https://doi.org/10.1016/j.bjorl.2014.05.020.

Wu YH, Wang YP, Kok SH, Chang JY. Unilateral nasopalatine duct cyst. J Formos Med Assoc. 2015;114(11):1142-4. doi: 10.1016/j.jfma.2015.08.005. »https://doi.org/10.1016/j.jfma.2015.08.005.

Lang MJ, Lee YP, Hwang MJ, Chiang CP. Nasopalatine duct cyst - case report. J Dent Sci. 2021;16(3):1047-9. doi: 10.1016/j.jds.2021.03.004. »https://doi.org/10.1016/j.jds.2021.03.004.

Yeom HG, Kang JH, Yun SU, Yoon JH. Nasopalatine duct cyst with sebaceous differentiation: a rare case report with literature review. BMC Oral Health. 2021;21(1):419. doi: 10.1186/s12903-021-01772-0. »https://doi.org/10.1186/s12903-021-01772-0.

Harris IR, Brown JE. Application of cross-sectional imaging in the differential diagnosis of apical radiolucency. Int Endod J. 1997;30(4):288-90. doi: 10.1046/j.1365-2591.1997.00062.x. »https://doi.org/10.1046/j.1365-2591.1997.00062.x.

Popli H, Singh H, Gupta A, Kamboj M. Peripheral ossifying fibroma veiling a nasopalatine duct cyst: an unusual concurrence. Indian J Otolaryngol Head Neck Surg. 2022;74(S2):1459-61. doi: 10.1007/s12070-021-02601-0. »https://doi.org/10.1007/s12070-021-02601-0.

Barros CC, Santos HB, Cavalcante IL, Rolim LS, Pinto LP, Souza LB. Clinical and histopathological features of nasopalatine duct cyst: A 47-year retrospective study and review of current concepts. J Craniomaxillofac Surg. 2018;46(2):264-8. doi: 10.1016/j.jcms.2017.11.014. »https://doi.org/10.1016/j.jcms.2017.11.014.

Nortjé CJ, Wood RE. The radiologic features of the nasopalatine duct cyst. An Analysis of 46 Cases. Dentomaxillofac Radiol. 1988;17(2):129-32. doi: 10.1259/dmfr.1988.0017. »https://doi.org/10.1259/dmfr.1988.0017.

Tsuneki M, Maruyama S, Yamazaki M, Abé T, Adeola HA, Cheng J, et al. Inflammatory histopathogenesis of nasopalatine duct cyst: a clinicopathological study of 41 cases. Oral Dis. 2013;19(4):415-24. doi: 10.1111/odi.12022. »https://doi.org/10.1111/odi.12022.

Rush J, Sulte H, Cohen D, Makkawy H. Course of infection and case outcome in individuals diagnosed with microbial colonies morphologically consistent with actinomyces species. J Endod. 2002;28(8):613-8. doi: 10.1097/00004770-200208000-00013.

»https://doi.org/10.1097/00004770-200208000-00013.

Acevedo F, Baudrand R, Letelier LM, Gaete P. Actinomycosis: a great pretender. Case reports of unusual presentations and a review of the literature. Int J Infect Dis. 2008;12:358-62. doi: 10.1016/j.ijid.2007.10.006. »https://doi.org/10.1016/j.ijid.2007.10.006.

Barnard D, Daviest J, Figdor D. Susceptibility of Actinomyces israelii to antibiotics, sodium hypochlorite and calcium hydroxide. Int Endod J. 1996;29(5):320-6. doi: 10.1111/j.1365-2591.1996.tb01392.x. »https://doi.org/10.1111/j.1365-2591.1996.tb01392.x.

Gulabivala K, Briggs PF. Diagnostic dilemma: an unusual presentation of an infected nasopalatine duct cyst. Int Endod J. 1992;25(2):107-11. doi: 10.1111/j.1365-2591.1992.tb00744.x. »https://doi.org/10.1111/j.1365-2591.1992.tb00744.x.

Modi K, Padmapriya R, Elango S, Arul B, Natanasabapathy V. Nonmalignant nonendodontic lesions mimicking periapical lesions of endodontic origin: a systematic review. J Conserv Dent. 2022;25(3):214-25. doi: 10.4103/jcd.jcd_13_22. »https://doi.org/10.4103/jcd.jcd_13_22.

Gnanasekhar JD, Walvekar SV, Al-Kandari AM, Al-Duwairi Y. Misdiagnosis and mismanagement of a nasoplatine duct cyst and its corrective therapy. A case report. Oral Surg, Oral Med, Oral Pathol, Oral Radiol Endod. 1995;80(4):465-70. doi: 10.1016/s1079-2104(05)80372-5. »https://doi.org/10.1016/s1079-2104(05)80372-5.

Blaya-Tarraga J, Cervera-Ballester J, Penarrocha-Oltra D, Penarrocha-Diago M. Periapical implant lesion: a systematic review. Med Oral Patol Oral Cir Bucal. 2017; 22(6):e737-e749. doi: 10.4317/medoral.21698. »https://doi.org/10.4317/medoral.21698.

Ortega A, Fariña V, Gallardo A, Espinoza I, Acosta S. Nonendodontic periapical lesions: a retrospective study in Chile. Int Endod J. 2007;40(5):386-90. doi: 10.1111/j.1365-2591.2007.01232.x. »https://doi.org/10.1111/j.1365-2591.2007.01232.x.

Lee HS, Yang S, Han JY, Kang JH, Kim JE, Huh KH, et al. Automatic detection and classification of nasopalatine duct cyst and periapical cyst on panoramic radiographs using deep convolutional neural networks. Oral Surg Oral Med Oral Pathol Oral Radiol. 2024;138(1):184-95. doi: 10.1016/j.oooo.2023.09.012. »https://doi.org/10.1016/j.oooo.2023.09.012.

Suter VG, Jacobs R, Brücker MR, Furher A, Frank J, von Arx T, et al. Evaluation of a possible association between a history of dentoalveolar injury and the shape and size of the nasopalatine canal. Clin Oral Investig. 2016;20(3):553-61. doi: 10.1007/s00784-015-1548-7.

»https://doi.org/10.1007/s00784-015-1548-7.

Janovic A, Bracanovic D, Antic S, Markovic-Vasiljkovic B. Morphological CBCT parameters for an accurate differentiation between nasopalatine duct cyst and the normal nasopalatine canal. Head Face Med. 2024;20(1):54. doi: 10.1186/s13005-024-00458-6

»https://doi.org/10.1186/s13005-024-00458-6.

Mraiwa N, Jacobs R, van Cleynenbreugel J, Sanderink G, Schutyser F, Suetens P, et al. The nasopalatine canal revisited using 2D and 3D CT imaging. Dentomaxillofac Radiol. 2004;33:396-402. doi: 10.1259/dmfr/53801969. »https://doi.org/10.1259/dmfr/53801969.

Benavides E, Krecioch JR, Connolly RT, Allareddy T, Buchanan A, Spelic D, et al. Optimizing radiation safety in dentistry: clinical recommendations and regulatory considerations. J Am Dent Assoc. 2024;155(4):280-93.e4. doi: 10.1016/j.adaj.2023.12.002

»https://doi.org/10.1016/j.adaj.2023.12.00.

Downloads

Published

2025-01-14

Issue

Vol. 33 (2025)

Section

Original Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Todo o conteúdo do periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons do tipo atribuição CC-BY.

 

 

How to Cite

Peña, D. E. R., Alves, M. de S., Xavier, S. P., Pinheiro, T. N., Santos, P. S. da S., Rubira-Bullen, I. R. F., Giraldo, A. M. C. ., Navarro, P. S. S. ., González-Pérez, L. V., Petranacci, C. M. C., Perez-Sayáns, M., Anbinder, A. L., Almeida, J. D., & Motta, A. C. F. (2025). Nasopalatine duct cyst: a multicenter retrospective study of 63 cases and an integrative review of the clinical, imaginological and histopathological aspects. Journal of Applied Oral Science, 33, e20240539. https://doi.org/10.1590/1678-7757-2024-0539