PCNA and p53 expression in oral leukoplakia with different degrees of keratinization
DOI:
https://doi.org/10.1590/S1678-77572006000400012Keywords:
Leukoplakia, Immunohistochemistry, p53, Proliferating cell nuclear antigen (PCNA)Abstract
Leukoplakias are oral lesions that may have many clinical and histological aspects and they are usually associated with malignancy when dysplastic alterations are shown. However, these transformations may occur in non-dysplastic lesions that show harmless clinical aspect. For this reason, the proposal was to study the p53 and PCNA immunohistochemical expression in non-dysplastic leukoplakias, trying to correlate the results only with the epithelial keratinization degree. For this, 24 leukoplakias degrees I, II and III of Grinspan were used, all of them located in oral mucosa. Most of the leukoplakias showed p53 and PCNA expression in their different keratinization degrees. The p53 marking was confined to the basal and parabasal layers, while the PCNA marking occurred in practically all epithelial layers. The expression pattern of these markers was histologically and statistically similar between the lesions with these keratinization variations. It was evident that non-dysplastic epithelium of leukoplakias showed submicroscopical signs of alterations that lead to malignant transformation, and that the keratinization degree did not correlate to a greater risk of this event.Downloads
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Published
2006-08-01
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Original Articles
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Todo o conteúdo do periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons do tipo atribuição CC-BY.
How to Cite
PCNA and p53 expression in oral leukoplakia with different degrees of keratinization . (2006). Journal of Applied Oral Science, 14(4), 276-280. https://doi.org/10.1590/S1678-77572006000400012