Analysis of the association between lactotransferrin (LTF) gene polymorphism and dental caries

Authors

  • Luiza Foltran Azevedo Pontifical Catholic University of Paraná; Center for Health and Biological Sciences
  • Giovana Daniela Pecharki Pontifical Catholic University of Paraná; Center for Health and Biological Sciences
  • João Armando Brancher Pontifical Catholic University of Paraná; Center for Health and Biological Sciences
  • Carlos Alberto Cordeiro Junior Pontifical Catholic University of Paraná; Center for Health and Biological Sciences
  • Kamilla Gabriella dos Santos Medeiros Pontifical Catholic University of Paraná; Center for Health and Biological Sciences
  • Alessandra Armstrong Antunes Pontifical Catholic University of Paraná; Center for Health and Biological Sciences
  • Eduardo Silva Arruda Pontifical Catholic University of Paraná; Center for Health and Biological Sciences
  • Renata Iani Werneck Pontifical Catholic University of Paraná; Center for Health and Biological Sciences
  • Luciana Reis de Azevedo Pontifical Catholic University of Paraná; Center for Health and Biological Sciences
  • Rui Fernando Mazur Pontifical Catholic University of Paraná; Center for Health and Biological Sciences
  • Samuel Jorge Moysés Pontifical Catholic University of Paraná; Center for Health and Biological Sciences
  • Simone Tetü Moysés Pontifical Catholic University of Paraná; Center for Health and Biological Sciences
  • Fábio Rueda Faucz Pontifical Catholic University of Paraná; Center for Health and Biological Sciences
  • Paula Cristina Trevilatto Pontifical Catholic University of Paraná; Center for Health and Biological Sciences

DOI:

https://doi.org/10.1590/S1678-77572010000200011

Keywords:

Dental caries^i1^socurre, LTF, Gene polymorphism, Exon 2

Abstract

OBJECTIVE: The present study evaluated the association between lactotransferrin (LTF) gene polymorphism (exon 2, A/G, Lys/Arg) and dental caries. MATERIAL AND METHODS: A convenience sample of 110 individuals, 12 years old, was divided into: group 1, 48 individuals without caries experience (DMFT=0), and group 2, 62 subjects with caries experience (DMFT>;1). DNA was obtained from a mouthwash with 3% glucose solution, followed by a scrapping of the oral mucosa. After DNA purification, polymerase chain reaction (PCR), single strand conformation polymorphism (SSCP) was performed to access the study polymorphism. The LTF A/G (Lys/Arg) polymorphism had been previously reported as located in exon 1. RESULTS: Allele 1 of the study polymorphism was associated with low DMFT index and showed a protective effect against caries experience (OR=0.16, IC=0.03-0.76, p=0.01). CONCLUSIONS: Lactotransferrin A/G (exon 2, Lys/Arg) polymorphism was associated with susceptibility to dental caries in 12-year-old students.

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Published

2010-04-01

Issue

Vol. 18 No. 2 (2010)

Section

Original Articles

License

Todo o conteúdo do periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons do tipo atribuição CC-BY.

 

 

How to Cite

Azevedo, L. F., Pecharki, G. D., Brancher, J. A., Cordeiro Junior, C. A., Medeiros, K. G. dos S., Antunes, A. A., Arruda, E. S., Werneck, R. I., Azevedo, L. R. de, Mazur, R. F., Moysés, S. J., Moysés, S. T., Faucz, F. R., & Trevilatto, P. C. (2010). Analysis of the association between lactotransferrin (LTF) gene polymorphism and dental caries . Journal of Applied Oral Science, 18(2), 166-170. https://doi.org/10.1590/S1678-77572010000200011