Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis

Authors

  • Giana da Silveira Lima Federal University of Pelotas; Department of Operative Dentistry
  • Gabriela Ferrari da Silva Federal University of Pelotas; Department of Operative Dentistry
  • Ana Paula Neutzling Gomes Federal University of Pelotas; Center for Diagnosis of Oral Diseases; Department of Semiology and Clinic
  • Lenita Maria Aver de Araújo Federal University of Pelotas; Center for Diagnosis of Oral Diseases; Department of Semiology and Clinic
  • Fernanda Gonçalves Salum Pontifical Catholic University of Rio Grande do Sul; São Lucas Hospital; Oral Medicine and Oral Maxillofacial Cancer Prevention Unit

DOI:

https://doi.org/10.1590/S1678-77572010000500018

Keywords:

Diclofenac, Hyaluronic acid, Cheilitis, Actinic rays, Oral leukoplakia

Abstract

OBJECTIVE: Actinic cheilitis (AC) is a precancerous lesion of the lip vermillion caused by prolonged exposure to ultraviolet light. The aim of this study was to evaluate the effect of 3% diclofenac in 2.5% hyaluronic acid gel in the treatment of AC. METHODS: Thirty-four patients with chronic AC were treated twice a day with topical diclofenac during a period of 30 to 180 days. The individuals were followed up every 15 days by means of clinical examination and digital photographic documentation. RESULTS: Of the 27 patients that completed the study, 12 (44%) showed complete remission of the whitish plaques and exfoliative areas, and 15 (56%) had partial remission of the clinical picture of cheilitis. The latter group was submitted to excision of the leukoplakic areas which diagnosis varied from mild to moderate epithelial dysplasia. CONCLUSIONS: The results suggest a promising role for diclofenac in hyaluronic acid gel in the treatment of AC. This treatment has the advantages of not being invasive and showing few side effects.

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Published

2010-10-01

Issue

Vol. 18 No. 5 (2010)

Section

Original Articles

License

Todo o conteúdo do periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons do tipo atribuição CC-BY.

 

 

How to Cite

Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis . (2010). Journal of Applied Oral Science, 18(5), 533-537. https://doi.org/10.1590/S1678-77572010000500018