Synthesis and determination of antimicrobial activity of 5-nitro-2-thiophylidene derivatives against MRSA

Authors

  • Andrea Masunari Universidade de São Paulo; Faculdade de Ciências Farmacêuticas; Departamento de Tecnologia Bioquímico-Farmacêutica; Laboratório de Planejamento e Desenvolvimento de Fármacos
  • Leoberto Costa Tavares Universidade de São Paulo; Faculdade de Ciências Farmacêuticas; Departamento de Tecnologia Bioquímico-Farmacêutica; Laboratório de Planejamento e Desenvolvimento de Fármacos

DOI:

https://doi.org/10.1590/S1516-93322006000300016

Keywords:

Staphylococcus aureus, Synthesis, MIC, Nifuroxazide, Multidrug-Resistance

Abstract

Infection diseases caused by methicillin-resistant Staphylococcus aureus have been an increasing problem worldwide presenting significant morbidity and mortality rates. Thus, fourteen benzoic acid [(5-nitro-thiophen-2-yl)-methylene]-hydrazides were designed, synthesized and tested against standard (ATCC 25923) and multidrug-resistant strains of Staphylococcus aureus. All compounds exhibited significant bacteriostatic activity and, in such cases, also bactericidal activity, especially the p-COCH3 derivative with MIC = 0.14 mg/mL. The results have demonstrated the potential of synthesized compounds as alternative to the development of selective antimicrobial agents.

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Published

2006-09-01

Issue

Vol. 42 No. 3 (2006)

Section

Original Papers

How to Cite

Synthesis and determination of antimicrobial activity of 5-nitro-2-thiophylidene derivatives against MRSA. (2006). Revista Brasileira De Ciências Farmacêuticas, 42(3), 461-471. https://doi.org/10.1590/S1516-93322006000300016