Study of tissue reaction caused by several concentracions of penicilin G. benzatin in rats

Abstract

The search of scientific answers to problems due to procedures involving professional actions is a permanent challenge to the nurses committed with the improving of nursing care. In face of the intensive muscle soreness provoked by penicilin (J benzatin shots, an experimental evaluation of this procedure was carried out in order to observe the influences of concentration and volumes used. This evaluation could give some insights to improve the nursing care, particularly those linked to the manipulation of the penicilin injection. The study was performed in the Faculty of Medicine of the University of São Paulo, in 27 Male Wistar rats. After the injection of the drug or saline solution in the right and left limb, respectively, the animals were sacrified and the muscles in which the solution were injected were histologically examined. The use of penicilin provoked intensive inflammatory reaction, the peak intensity being attained after 48 hours. A remaining effect lasted about thirty days. The inflamatory reaction was similar for the three concentrations of penicilin. Nevertheless, the present research does not bring data that should modify the current injection procedures.