Cytotoxicity of PVC tubes sterilized in ethylene oxide after gamma radiation exposure

Authors

  • Rafael Queiroz de Souza Universidade de São Paulo; Escola de Enfermagem
  • Kazuko Uchikawa Graziano Universidade de São Paulo; Escola de Enfermagem; Departamento de Enfermagem Médico-Cirúrgica
  • Tamiko Ichikawa Ikeda Instituto Adolfo Lutz; Núcleo de Cultura de Células
  • Cláudia Regina Gonçalves Instituto Adolfo Lutz; Núcleo de Cultura de Células
  • Áurea Silveira Cruz Instituto Adolfo Lutz; Núcleo de Cultura de Células

DOI:

https://doi.org/10.1590/S0080-62342013000200031

Keywords:

Sterilization, Gamma rays, Ethylene oxide, Nursing

Abstract

Do materials sterilized using gamma rays become toxic when re-sterilized in ethylene oxide? This question guided the objective of this study, which was to investigate the potential cytotoxic effect of PVC sterilized by gamma radiation and re-sterilized with EO by the agar diffusion method in cell cultures. Nine PVC tubes were subjected to gamma radiation sterilization and were re-sterilized in EO. The tubes were divided into a total of 81 units of analysis that were tested so as to represent the internal and external surfaces and mass of each tube. It was concluded that the PVC materials sterilized in gamma radiation and re-sterilized in EO are not cytotoxic.

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Published

2013-04-01

Issue

Vol. 47 No. 2 (2013)

Section

Original Article

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

Souza, R. Q. de, Graziano, K. U., Ikeda, T. I., Gonçalves, C. R., & Cruz, Áurea S. (2013). Cytotoxicity of PVC tubes sterilized in ethylene oxide after gamma radiation exposure. Revista Da Escola De Enfermagem Da USP, 47(2), 494-499. https://doi.org/10.1590/S0080-62342013000200031