A infecção do HPV como fator de risco para o carcinoma de células escamosas de esôfago e seu prognóstico
DOI:
https://doi.org/10.11606/issn.1679-9836.v100i2p144-151Palavras-chave:
Infecção por HPV, Infecção por Papilomavírus Humano, Neoplasia de esôfago, Prognóstico, Câncer de esôfagoResumo
O câncer de esôfago é o 8º mais comum no mundo, com uma taxa de sobrevida em torno de 20% em cinco anos. O tipo histológico mais frequente é o carcinoma de células escamosas, o qual apresenta variações geográficas e étnicas. Os fatores de riscos para tal patologia não são bem definidos. Um dos principais é a infecção pelo Papiloma Vírus Humano (HPV), que apresenta quadros frequentes, porém transitórios, podendo regredir espontaneamente. Os subtipos que apresentam maior risco de malignidade são o 16 e 18. Dessa forma, uma revisão sistemática da literatura foi realizada a partir da base de dados de referência, como Medline, The Cochrane Library, Embase, Lilacs. Foram aplicados os critérios de exclusão e inclusão e assim obteve o resultado e assim 25 artigos incluídos nessa revisão e 39 excluídos. O estudo demonstrou presença do HPV no CEC de esôfago em 648 (24,4%) das 2647 amostras de tecidos neoplásicos, detectados através de diferentes técnicas. O que foi observado, todavia, é que essa grande prevalência muito se relaciona à região geográfica estudada. Por fim, foi considerado que de fato existe uma relação entre o HPV e o CEC de esôfago, como analisado na grande maioria dos estudos, porém ainda não se pode chegar a uma conclusão efetiva acerca da sua interferência no prognóstico do paciente.
Downloads
Referências
Tiftikçi A, Kutsal E, Altıok E, et al. Analyzing esophageal squamous cell papillomas for the presence of human papilloma virus. Turk J Gastroenterol. 2017;28:176-8. doi: 10.5152/tjg.2017.16636.
Instituto Nacional de Câncer. Câncer de esôfago [atualização 22 out. 2018]. Disponível em: https://www.inca.gov.br/tipos-de-cancer/cancer-de-esofago.
Tustumi F, Kimura CMS, Takeda RH, et al. Fatores prognósticos e análise de sobrevida no carcinoma esofágico. ABCD Arq Bras Cir Dig. 2016;29(3):138-41. doi: 10.1590/0102-6720201600030003.
Cao F, Han H, Zhang F, Wang B, et al. HPV infection in esophageal squamous cell carcinoma and its relationship to the prognosis of patients in northern China. Scientific World J. 2014;2014:804738. doi: 10.1155/2014/804738.
Dreilich M, Bergqvist M, Moberg M, Brattström D, Gustavsson I, et al. High-risk human papilloma virus (HPV) and survival in patients with esophageal carcinoma: a pilot study. BMC Cancer 2006, 6:94. doi: 10.1186/1471-2407-6-94.
Furihata M, Ohtsuki Y, Ogoshi S, et al. Prognostic significance of human papillomavirus genomes (type‐16, ‐18) and aberrant expression of p53 protein in human esophageal cancer. IJC 1993, 2910540211. doi: 10.1002/ijc.2910540211.
Kumar R1, Ghosh SK, Verma AK, et al. p16 expression as a surrogate marker for HPV infection in esophageal squamous cell carcinoma can predict response to neo-adjuvant chemotherapy. Asian Pac J Cancer Prev. 2015;16(16):7161-5. doi: 10.7314/apjcp.2015.16.16.7161.
Souto Damin AP, Guedes Frazzon AP, de Carvalho Damin D, et al. Detection of human papillomavirus DNA in squamous cell carcinoma of the esophagus by auto-nested PCR. Dis Esophagus. 2006;19(2):64-8. doi: 10.1111/j.1442-2050.2006.00541.x.
Wang WL, Wang YC, Lee CT, et al. The impact of human papillomavirus infection on the survival and treatment response of patients with esophageal cancers. J Dig Dis. 2015;16(5):256-63. doi: 10.1111/1751-2980.12236.
Mehryar M, Li SY, et al. Prevalence of human papillomavirus in esophageal carcinoma in Tangshan, China. World J Gastroenterol. 2015;21(10):2905-2911. doi: 10.3748/wjg.v21.i10.2905.
Türkay DÖ, Vural Ç, et al. Detection of human papillomavirus in esophageal and gastroesophageal junction tumors: A retrospective study by real-time polymerase chain reaction in an instutional experience from Turkey and review of literature. Pathol Res Pract. 2016;212(2):77-82. doi: 10.1016/j.prp.2015.10.007.
Soheili F, Heidary N, Rahbar M, et al. Human papillomavirus and its clinical relevance in oesophageal squamous cell carcinoma in a Kurdish population in the west of Iran. Infect Dis (Lond). 2016 Apr;48(4):270-273. doi: 10.3109/23744235.2015.1109134.
Prakash Saxena P U, Fernandes DJ, Vidyasagar MS, Singh A, Sharan K. Detection of human papilloma virus in patients with squamous cell carcinoma of the esophagus planned for definitive chemo-radiotherapy, and a study of their clinical characteristics. J Can Res Ther 2016;12:871-5. doi: 10.4103/0973-1482.168971.
Costa AM, Tavares Guerreiro Fregnani JH, et al. HPV infection and p53 and p16 expression in esophageal cancer: are they prognostic factors? Infect Agents Cancer. 2017;12:54. doi: 10.1186/s13027-017-0163-4.
Bahnassy AA, Zekri AR, Abdallah S, El-Shehaby AM, Sherif GM. Human papillomavirus infection in Egyptian esophageal carcinoma: correlation with p53, p21, mdm2, C-erbB2 and impact on survival. Pathol Int. 2005;55(2):53-62. doi: 10.1111/j.1440-1827.2005.01804.x.
Zhang D, Zhang W, Liu E, et al. Human papillomavirus infection increases the chemoradiation response of esophageal squamous cell carcinoma based on P53 mutation. Radiother Oncol. 2017;124(1):155-60. doi: 0.1016/j.radonc.2017.06.008.
GeßnerAL, Borkowetz A, Baier M, et al. Detection of HPV16 in Esophageal Cancer in a High-Incidence Region of Malawi. Int J Mol Sci. 2010;19(2):557. doi: 10.3390/ijms19020557.
Haeri H, Mardani O, Asadi-Amoli F, et al. Human papilloma virus and esophageal squamous cell carcinoma. Acta Med Iran. 2014;52(3):197-200.
Farhadi M, Tahmasebi Z, Merat S, et al. Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population. World J Gastroenterol. 2005;11(8):1200-3. doi: 10.3748/wjg.v11.i8.1200.
Antonsson A, Nancarrow DJ, Brown IS, et al. High-risk human papillomavirus in esophageal squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2010; 19(8):2080-7. doi: 10.1158/1055-9965.EPI-10-0033.
Guo F, Liu Y, Wang X, et al. Human papillomavirus infection and esophageal squamous cell carcinoma: a case-control study. Cancer Epidemiol Biomarkers Prev. 2012;21(5):780-5. doi: 10.1158/1055-9965.EPI-11-1206.
Benamouzig R, Pigot F, Quiroga G, et al. Human papillomavirus infection in esophageal squamous-cell carcinoma in western countries. Int J Cancer. 1992;50(4):549-52. doi: 10.1002/ijc.2910500409.
Talamini G, Capelli P, Zamboni G, et al. Alcohol, smoking and papillomavirus infection as risk factors for esophageal squamous-cell papilloma and esophageal squamous-cell carcinoma in Italy. Int J Cancer. 2000;86(6):874-8. doi: 10.1002/ijc.2910500409.
Haohua Teng, Xiaojing Li, Xiuping Liu, et al. The absence of human papillomavirus in esophageal squamous cell carcinoma in East China Int J Clin Exp Pathol. 2014;7(7):4184-93.
Hayedeh Haeri, Mardani O, Asadi-Amoli F, et al. Human papilloma virus and esophageal squamous cell carcinoma. Acta Med Iran. 2014;52(3):197-200.
Herbster S, Ferraro CT, Koff NK, et al. HPV infection in Brazilian patients with esophageal squamous cell carcinoma: interpopulational differences, lack of correlation with surrogate markers and clinicopathological parameters. Cancer Lett. 2012; 29; 326(1):52-8. doi: 10.1016/j.canlet.2012.07.018.
Dąbrowski A., Kwaśniewski W., Skoczylas T, et al. Incidence of human papilloma virus in esophageal squamous cell carcinoma in patients from the Lublin region. World J Gastroenterol. 2012;18(40):5739-44. doi: 10.3748/wjg.v18.i40.5739.
Herrera-Goepfert R, Lizano M, Akiba S, et al. Human papilloma virus and esophageal carcinoma in a Latin-American region. World J Gastroenterol. 2009;15(25):3142-7. doi: 10.3748/wjg.15.3142.
Syrjänen K, Pyrhönen S, Aukee S, et al. Squamous cell papilloma of the esophagus: a tumour probably caused by human papilloma virus (HPV). Diagn Histopathol. 1982;5:291-6.
Pantham G, Ganesan S, Einstadter D. Assessment of the incidence of squamous cell papilloma of the esophagus and the presence of high-risk human papilloma virus. Dis Esophagus. 2017;1;30(1):1-5. doi: 10.1111/dote.12475.
Ludmir EB, Stephens SJ, Palta M, et al. Human papillomavirus tumor infection in esophageal squamous cell carcinoma. J Gastrointest Oncol. 2015;6(3):287-95. doi: 10.3978/j.issn.2078-6891.2015.001.
Zhang SK, Guo Lw, Chen Q, et al. Prevalence of human papillomavirus 16 in esophageal cancer among the Chinese population: a systematic review and meta-analysis. Asian Pacific Journal of Cancer Prevention. APJCP. 2014;15(23):10143-9. doi: 10.7314/apjcp.2014.15.23.10143.
Guo LW, Zhang SK, Liu SZ, et al. Human papillomavirus type-18 prevalence in oesophageal cancer in the Chinese population: a meta-analysis. Epidemiol Infect. 2016;144(3):469-77. doi: 10.1017/S0950268815001703.
Li X, Gao C, Yang Yet al. Systematic review with meta-analysis: the association between human papillomavirus infection and esophageal cancer. Aliment Pharmacol Ther. 2014;39(3):270-81. doi: 10.1111/apt.12574.
Guo L, Liu S, Zhang S, et al. Human papillomavirus-related esophageal cancer survival: a systematic review and meta-analysis. Medicine (Baltimore). 2016; 95(46):e5318. doi: 10.1097/MD.0000000000005318.
Downloads
Publicado
Edição
Seção
Licença
Copyright (c) 2021 Ana Carolina Ferrari Nassar, Débora de Oliveira Garcia, Júlia Royd Costa Salvio, Nathalie Gabrielle Gomes Lessa Altieri, Letícia Pacolla Izique, Carolina Isper, Gilberto Mendes Menderico Junior
Este trabalho está licenciado sob uma licença Creative Commons Attribution-ShareAlike 4.0 International License.
