Clinical and laboratory manifestations of the new coronavirus (COVID-19) in pregnant women and analysis of the possible risk of vertical intrauterine transmission: a systematic review
DOI:
https://doi.org/10.11606/issn.1679-9836.v99i6p601-608Keywords:
COVID-19, Pregnant, Neonates, CoronavirusAbstract
The pandemic numbers of the new coronavirus have surpassed the other members of the Coronaviridae family, accumulating until today, more than 24 million cases of the disease. The knowledge acquired by previous outbreaks suggests that pregnant women and their fetuses are more susceptible to poor prognosis. The purpose of this review is to verify the manifestations of the SARS-CoV-2 infection in pregnant women and the risk of vertical transmission. To begin, this review has included manuscripts that, all together, presented data from 205 pregnant women and 76 neonates. Among the results, the symptoms presented by pregnant women were the same as non-pregnant patients, as well as laboratory alterations, such as lymphopenia and ground glass opacity on computed tomography. In total, 163 cesarean sections were performed with an indication of impaired respiratory status, with the death of only one patient. Regarding the results of testing the new coronavirus in neonates, only one neonate with his study published in July 2020 met the diagnostic criteria for congenital infection by SARS-CoV-2. The other five neonates who were positive soon after birth, did not present the correct tests and was not ruled out the risk of infection during delivery and the first hours. At last, studies are necessary to support the exact risk of vertical transmission, assessing the influence of maternal viral load and other data such as the gestational age of greatest risk for transmission.
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