Terapia a longo prazo com lítio e o risco de danos renais: revisão integrativa da literatura
DOI:
https://doi.org/10.11606/issn.1679-9836.v101i2e-193028Palavras-chave:
Carbonato de lítio, Efeitos adversos, RimResumo
Este estudo objetivou avaliar os potenciais efeitos adversos nos rins associado ao tratamento de longo prazo com lítio em pacientes com transtorno bipolar, a partir de uma revisão integrativa literatura. Os artigos foram identificados nas bases de dados SciELO, Medline (Pubmed) e Biblioteca Virtual em Saúde (BVS), publicados entre 2010 e 2021. Aplicados os critérios de inclusão e exclusão, identificaram-se 18 artigos para a análise. Verificou-se que o tratamento com lítio durante um período prolongado está associado à redução da taxa de filtração glomerular, porém, outras variáveis devem ser consideradas como idade e comorbidades associadas. Por outro lado, não foi associado evolução da doença renal crônica em estágio terminal por uso do medicamento. A investigação dos estudos revelou que a droga em doses terapêuticas e com monitoramento laboratorial contínuo não demonstrou toxicidade ou efeitos colaterais severos nos rins sendo a sua descontinuação relacionada com exarcebações do humor.
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Copyright (c) 2022 Jefferson Pereira Sarmento, José Valdilânio Virgulino Procópio, Rafaela de Oliveira Nóbrega
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