Melitina: o uso do principal componente da peçonha de abelha no combate de linhagens de células tumorais pulmonares
DOI:
https://doi.org/10.11606/issn.1679-9836.v101i6e-200516Palavras-chave:
Antineoplásicos, Peptídeos, NanopartículasResumo
Introdução: Melitina é um peptídeo formado por 26 aminoácidos e principal composto da peçonha produzida por abelhas do gênero Apis. Estudos pré-clínicos têm demonstrado uma capacidade antineoplásica do composto, evidenciando seu efeito sobre linhagens celulares de câncer. O câncer de pulmão é o câncer que mais mata no mundo, sendo que 90% dos casos da doença estão relacionados a um histórico tabagista. O diagnóstico tardio muitas vezes devido à falta de sintomas clínicos compromete diretamente o tratamento e o prognóstico, gerando uma baixa taxa de sobrevida. Neste sentido, a melitina surge como uma abordagem no tratamento de câncer de pulmão. Objetivo: Realizar uma revisão integrativa da literatura sobre as pesquisas publicadas nos últimos cinco anos sobre o efeito da melitina em linhagens de células tumorais pulmonares humanas. Resultados: Foram encontradas 15 publicações, 10 foram excluídas por não responderem diretamente ao objetivo proposto ou por se tratarem de artigos duplicados e cinco foram escolhidas para compor esta revisão. Discussão: Os artigos avaliados relatam o efeito anticancerígeno da melitina sobre linhagens celulares de câncer de pulmão in vitro e in vivo. Conclusão: Devido sua atividade citotóxica a melitina é uma candidata no desenvolvimento de novos tratamentos de câncer.
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