Qual a importância das tenascinas na fisiopatologia de diversas doenças?
DOI:
https://doi.org/10.11606/issn.1679-9836.v103i2e-209844Palavras-chave:
Tenascinas, Fisiopatologia, DoençasResumo
As tenascinas são um grupo de proteínas que compõem a matriz extracelular de diferentes tecidos. Estão envolvidas com a sinalização e função estrutural de diferentes órgãos, o que justifica o desenvolvimento de estudos devido sua relação com doenças em diferentes sistemas. Nosso objetivo foi lançar luz, através de uma revisão, mostrando as vias de envolvimento que as tenascinas têm em diferentes distúrbios orgânicos. Cada tipo de tenascina está relacionada com uma desordem específica. A tenascina X está envolvida no desencadeamento de doenças do colágeno, enquanto a tenascina C e W destacam-se em situações de trauma, inflamação e tumores. A tenascina R está envolvida exclusivamente no sistema nervoso central e na migração neuronal e no processo de diferenciação. Compreender o real papel dessas proteínas é um recurso valioso para a compreensão da fisiopatologia de diversas doenças, além de possibilitar a pesquisa de novos métodos diagnósticos e a prospecção de alvos terapêuticos para o desenvolvimento de fármacos.
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Copyright (c) 2024 Larissa Cristina França Santos, Marjory Pacheco dos Santos, Cristian Rodrigues do Nascimento, Raphael Lopes Cavalcante, Rodrigo Mendes, Pedro Pereira Tenório
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