Severity of acute appendicitis based on laboratory data
DOI:
https://doi.org/10.11606/issn.1679-9836.v104i1e-225750Keywords:
Appendicitis, Appendectomy, Indicators of morbidity and mortality;, Perioperative periodAbstract
Objective: This study aims to predict the severity of acute appendicitis using routine laboratory tests, enabling earlier and more personalized diagnoses. Given the prevalence and diagnostic complexity of acute appendicitis, the goal is to help reduce perioperative morbidity and mortality associated with the condition. Methods: The research was conducted at the Regional Hospital of São José Dr. Homero de Miranda Gomes, involving 200 patients diagnosed with acute appendicitis and undergoing appendectomy between May 1, 2022, and January 31, 2023. Conducted prospectively, demographic data, laboratory tests (complete blood count, C-reactive protein (CRP), total cholesterol, albumin, and lactate), and the degree of appendicitis by transoperative evaluation were analyzed. Statistical analysis was performed using the Mann-Whitney U test for laboratory variable. Results: Among the 200 patients, 111 (55.5%) had uncomplicated appendicitis (grades 1 and 2), while 89 (44.5%) had complicated appendicitis (grades 3, 4, and 5). The analysis revealed statistically significant differences in variables such as white blood cells, neutrophils, eosinophils, lymphocytes, total cholesterol, albumin, and CRP between the groups of uncomplicated and complicated appendicitis. The ratios between neutrophils/lymphocytes (NLR), lymphocytes/monocytes (LMR), and albumin/CRP (ACR) also showed significant statistical differences. Conclusion: The results indicate that selected laboratory markers can be useful indicators in predicting the severity of acute appendicitis. These findings provide the basis for future investigations aimed at optimizing the clinical approach to appendicitis, contributing to moreeffective and personalized interventions.
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