Prevalência de transtornos do humor e ansiedade em pessoas com epilepsia: uma revisão sistemática
DOI:
https://doi.org/10.11606/issn.1679-9836.v103i4e-226358Palavras-chave:
Transtornos da Ansiedade, Prevalência, Epilepsia, Transtornos do HumorResumo
Introdução: A epilepsia é reconhecida como um grupo de doenças crônicas não transmissíveis que têm em comum crises epilépticas recorrentes e está associada a maior predisposição a comorbidades psiquiátricas. Embora os transtornos de humor e de ansiedade ocorram frequentemente em pessoas com epilepsia e prejudiquem a qualidade de vida e os resultados do tratamento, os estudos atuais para investigar essas comorbidades permanecem com resultados insatisfatórios para a população com epilepsia nos países em desenvolvimento. Objetivos: Descrever a frequência dos transtornos de humor e ansiedade e as características clínicas e sociodemográficas de pessoas com epilepsia que apresentam esses transtornos. Métodos: Revisão de literatura nas bases de dados EMBASE, LILACS, PsycINFO, Pubmed e Scielo. Foram incluídos estudos transversais publicados nos últimos 5 anos, nos idiomas português e inglês, que avaliaram comorbidades em indivíduos com 18 anos ou mais com diagnóstico de epilepsia atendendo aos critérios da Liga Internacional Contra a Epilepsia. Resultados: Nossa busca rastreou 3.054 artigos, dos quais 3.047 foram excluídos por publicação duplicada e por serem incompatíveis com o tema devido a critérios de elegibilidade. Os resultados encontrados para diagnósticos psiquiátricos variaram de 18% a 52,6% para prevalência de transtornos de humor e de 6,5% a 33,4% para transtornos de ansiedade. Conclusão: Esta revisão encontrou maior prevalência de transtornos de humor e ansiedade em pessoas com epilepsia. Dessa forma, os médicos responsáveis pelo tratamento de pessoas com epilepsia devem estar atentos ao aumento das chances de transtornos de humor e ansiedade nesta população, a fim de realizar uma abordagem adequada a estes pacientes.
Downloads
Referências
Who.int. 2021. Epilepsy. WHO. 2021. https://www.who.int/news-room/factsheets/detail/epilepsy.
Mula M, Kanner AM, Jetté N, Sander JW. Psychiatric Comorbidities in People With Epilepsy. Neurol Clin Pract. 2021;11:e112-20. Doi: https://doi.org/10.1212/CPJ.0000000000000874.
Allers K, Essue BM, Hackett ML, Muhunthan J, Craig S. The economic impact of epilepsy: a systematic review. BMC Neurol. 2015;15(1):245. Doi: https://doi.org/10.1186/s12883-015-0494-y
Ngugi AK, Kariuki SM, Bottomley C, Kleinschmidt I, Sander JW, Newton CR. Incidence of epilepsy: A systematic review and metaanalysis. Neurology. 2011;77(10):1005-12. Doi: https://doi.org/10.1212/wnl.0b013e31822cfc90
Li LM, Fernandes PT, Noronha ALA, Marques LHN, Borges MA, Cendes F, et al.. Demonstration project on epilepsy in Brazil: situation assessment. Arq Neuro-Psiquiatr [Internet]. 2007;65:5-13. Doi: https://doi.org/10.1590/S0004-282X2007001000002
Sen A, Jette N, Husain M, Sander JW. Epilepsy in older people. The Lancet 2020;395:735-48. Doi: https://doi.org/10.1016/S0140-6736(19)33064-8.
Kobau R, Gilliam F, Thurman DJ. Prevalence of self-reported epilepsy or seizure disorder and its associations with self-reported depression and anxiety: results from the 2004 healthstyles survey. Epilepsia. 2006;47(11):1915-21. Doi: https://doi.org/10.1111/j.1528-1167.2006.00612.x
Mula M, von Oertzen TJ, Cock HR, Lozsadi DA, Agrawal N. Clinical correlates of memory complaints during AED treatment. Acta Neurol Scand. 2016;134(5):368-73. Doi: https://doi.org/10.1111/ane.12553
Nogueira MH, Yasuda CL, Coan AC,Kanner AM, Cendes F. Concurrent mood and anxiety disorders ar associated with pharmacoresistant seizures in patients with MTLE. Epilepsia. 2017;58(7):1268-76. Doi: https://doi.org/10.1111/epi.13781
Gómez-Arias B, Crail-Meléndez D, López-Zapata R, Martínez-Juárez IE. Severity of anxiety and depression are related to a higher perception of adverse effects of antiepileptic drugs. Seizure. 2012;21(8):588-94. Doi: https://doi.org/10.1016/j.seizure.2012.06.003
Hitiris N, Mohanraj R, Norrie J, Sills G, Brodie MJ. Predictors of pharmacoresistant epilepsy. Epilepsy Res. 2007;75(2–3):192-6. Doi: https://doi.org/10.1016/j.eplepsyres.2007.06.003
Mesraoua B, Deleu D, Hassan AH, Gayane M, Ali MA, Tomson T, et al. Dramatic outcomes in epilepsy: depression, suicide, injuries, and mortality. Curr Med Res Opin. 2020;36(9):1473-80. Doi: https://doi.org/10.1080/03007995.2020.1776234
Patel AD, Baca C, Franklin G, Herman ST, Hughes I, Meunier L, et al. Quality improvement in neurology: Epilep Qual Measur. 2017;91(18):829-36. Doi: https://doi.org/10.1212/wnl.0000000000006425
Lopez MR, Schachter SC, Kanner AM. Psychiatric comorbidities go unrecognized in patients with epilepsy: “You see what you know”. Epilepsy Behav. 2019;98:302-5. Doi: https://doi.org/10.1016/j.yebeh.2019.01.027
Mula M, Cock HR. More than seizures: improving the lives of people with refractory epilepsy. Eur J Neurol. 2015;22(1):24-30. Doi: https://doi.org/10.1111/ene.12603
Pham T, Sauro KM, Patten SB, et al. The prevalence of anxiety and associated factors in persons with epilepsy. Epilepsia. 2017;58(8):e107–10. https://doi.org/10.1111/epi.13817
Amruth G, Praveen-Kumar S, Nataraju B, Kasturi P. Study of psychiatric comorbidities in epilepsy by using the Mini International Neuropsychiatric Interview. Epilepsy Behav. 2014;33:94-100. Doi: https://doi.org/10.1016/j.yebeh.2014.02.001
Chaka A, Awoke T, Yohannis Z, Ayano G, Tareke M, Abate A. Determinants of depression among people with epilepsy in Central Ethiopia. Ann Gen Psychiat. 2018;17:27. Doi: https://doi.org/10.1186/s12991-018-0197-z.
Wang H-J, Tan G, Deng Y, He J, He YJ, Zhou D, et al. Prevalence and risk factors of depression and anxiety among patients with convulsive epilepsy in rural West China. Acta Neurol Scand. 2018;138:541-7. Doi: https://doi.org/10.1111/ane.13016.
Kuladee S, Prachason T, Srisopit P, Trakulchang D, Boongird A, Wisajan P, et al. Prevalence of psychiatric disorders in Thai patients with epilepsy. Epilepsy Behav. 2019;90:20-4. Doi: https://doi.org/10.1016/j.yebeh.2018.11.004.
Grzegorzewska AM, Wiglusz MS, Landowski J, Jakuszkowiak-Wojten K, Cubała W, Włodarczyk A, et al. Multiple Comorbidity Profile of Psychiatric Disorders in Epilepsy. JCM. 2021;10:4104. Doi: https://doi.org/10.3390/jcm10184104.
Zhong R, Chen Q, Li N, et al. Sex-based differences in the prevalence of and risk factors for depression in adult patients with epilepsy in Northeast China. Epilepsy Behav. 2021;122:108201. https://doi.org/10.1016/j.yebeh.2021.108201.
Zhong R, Chen Q, Li M, Li N, Zhang X, Lin W. Sex differences in anxiety in patients with epilepsy: Status and risk factors analysis. Epilepsy Behav. 2021;116. Doi: https://doi.org/10.1016/j.yebeh.2021.107801.
Kanner AM. The Complex Epilepsy Patient: Intricacies of Assessment and Treatment. Epilepsia. 2003;44(Suppl.5):S3-S8. Doi: https://doi.org/10.1046/j.1528-1157.44.s.5.2.x
Bragatti JA, Torres CM, Londero RG, Martin KC, Souza AC, Hidalgo MPL, et al. Prevalence of psychiatric comorbidities in temporal lobe epilepsy in a Southern Brazilian population. Arq Neuro-Psiquiatr. 2011;69:159-65. Doi: https://doi.org/10.1590/S0004-282X2011000200003.
Who.int. Depression. n.d. WHO. 2021. https://www.who.int/news-room/fact-sheets/detail/depression.
Who int. Depression and other common mental disorders: global health estimates [Internet]. Geneva: WHO. 2017. http://apps.who.int/iris/bitstream/10665/254610/1/WHO-MSD-MER-2017.2-eng.pdf
Josephson CB, Jetté N. Psychiatric comorbidities in epilepsy. International Review of Psychiatry. 2017;29:409-24. Doi: https://doi.org/10.1080/09540261.2017.1302412.
Scott AJ, Sharpe L, Hunt C, Gandy M. Anxiety and depressive disorders in people with epilepsy: A meta-analysis. Epilepsia. 2017;58:973–82. Doi: https://doi.org/10.1111/epi.13769.
Kanner AM. Psychiatric issues in epilepsy: The complex relation of mood, anxiety disorders, and epilepsy. Epilepsy Behav. 2009;15:83-7. Doi: https://doi.org/10.1016/j.yebeh.2009.02.034.
Vazquez B, Devinsky O. Epilepsy and anxiety. Epilepsy & Behavior. 2003;4:20-5. Doi: https://doi.org/10.1016/j.yebeh.2003.10.005.
Kanner AM. Depression in epilepsy: a complex relation with unexpected consequences. Curr Opin Neurol. 2008;21:190-4. Doi: https://doi.org/10.1097/WCO.0b013e3282f4e978.
Torres, C. Fatores de risco para transtornos de ansiedade na epilepsia do lobo temporal. [Internet] 2010. http://www.lume.ufrgs.br/bitstream/handle/10183/26137/000757143.pdf?sequence=1.
Michelin AP, Maes MHJ, Supasitthumrong T, Limotai, C, Matsumoto AK, Semeão LO, et al. Reduced paraoxonase 1 activities may explain the comorbidities between temporal lobe epilepsy and depression, anxiety and psychosis. World J Psych. 2022;12:308-22. Doi: https://doi.org/10.5498/wjp.v12.i2.308.
Lane C, Crocker C, Legg K, Borden M, Pohlmann-Eden B. Anxiety and Depression in Adult First Seizure Presentations. Canad J Neurol Scien. 2018;45:144-9. Doi: https://doi.org/10.1017/cjn.2017.285.
Rodríguez CA, Kubis MM, Arteaga CBT, Fustes OJH. Psychiatric Comorbidities in Epilepsy. J Epilepsy Res. 2022;12:21-6. Doi: https://doi.org/10.14581/jer.22004.
Downloads
Publicado
Edição
Seção
Licença
Copyright (c) 2024 Lucas Santana Dutra, Calil Darzé Neto

Este trabalho está licenciado sob uma licença Creative Commons Attribution-ShareAlike 4.0 International License.