Rhodiola rosea L. reduz os sintomas de depressão – revisão sistemática
DOI:
https://doi.org/10.11606/issn.1679-9836.v104i6e-227539Palavras-chave:
Transtorno depressivo, Crassulaceae, AntidepressivosResumo
Introdução: A patofisiologia da depressão tem sido associada com a atrofia do hipocampo, inflamação neural, baixa atividade de neurotransmissores monoaminérgicos e altos níveis de cortisol. Antidepressivos tradicionais têm efeitos colaterais, os quais levam pacientes a abandonar o tratamento. Alternativas naturais estudadas incluem o uso de Rhodiola rosea L. (RR) no tratamento de depressão leve a moderada. Esta revisão sistemática foi realizada para verificar a efetividade da RR em humanos com depressão leve a moderada. Métodos: As bases de dados PubMed, Scopus, Web of Science, Lilacs, Embase e Science Direct foram utilizadas para a busca dos estudos. Os termos “Salidroside”; “Rhodioloside”; “Rhodiola rosea”; “depression”; “depressive disorder”; “depression, chemical” e “human” foram utilizados. Estudos que atenderam aos critérios de elegibilidade, bem como suas qualidades metodológicas, foram avaliados por dois revisores. Resultados: O extrato de RR foi avaliado em três estudos e reduziu a intensidade dos sintomas em humanos com depressão leve a moderada com base na escala Hamilton e Inventário de Depressão de Beck. Conclusão: O uso de extrato de Rhodiola rosea reduz a severidade dos sintomas da depressão.
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