Validação do protocolo 4-C mortality score na estratificação de risco da covid-19 em pacientes internados em um hospital do Distrito Federal
DOI:
https://doi.org/10.11606/issn.1679-9836.v104i1e-229565Palavras-chave:
4-c Mortality Score, COVID-19, Regras de Decisão ClínicaResumo
A pandemia de COVID-19 impõs desafios aos sistemas de saúde globalmente, incluindo sobrecarga nos serviços de saúde. O objetivo deste estudo foi avaliar a acurácia do 4-C Mortality Score para prever o risco de mortalidade em pacientes com COVID-19 em um hospital público do Distrito Federal. Foi conduzido um estudo retrospectivo com 177 pacientes, utilizando o escore para prever desfechos clínicos, como alta hospitalar ou morte. A taxa de mortalidade observada foi de 15,25%, com 12,99% das mortes ocorrendo nos grupos de risco alto e muito alto segundo o escore. A área sob a curva (AUC) para os grupos de risco foi de 0,748 (0,641 - 0,855), resultando em um desempenho similar ao observado em estudos internacionais. Os resultados indicam que o 4-C Mortality Score pode ser útil para a estimativa de prognóstico em pacientes com COVID-19, auxiliando na tomada de decisões clínicas. No entanto, são necessários mais estudos em diferentes regiões do Brasil para validar esses achados, e a imunização dos pacientes contra COVID-19 não foi considerada nesta análise.
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Referências
World Health Organization. WHO COVID-19 Dashboard, Geneva, 2021. https://covid19.who.int
Noronha KV, Guedes GR, Turra CM, et al. Pandemia por COVID-19 no Brasil: análise da demanda e da oferta de leitos hospitalares e equipamentos de ventilação assistida segundo diferentes cenários. Cad Saude Publica. 2020;36(6):e00115320. Doi: 10.1590/0102-311X00115320. https://www.scielo.br/j/csp/a/XMbMhFTGYx5v7LtrTC58TcW/. Acesso em: 2 mar. 2021.
Da Silva MH, Procópio IM. A fragilidade do sistema de saúde brasileiro e a vulnerabilidade social diante da COVID-19. Rev Bras Promoc Saude. 2020;33:e10724. Doi: 10.5020/18061230.2020.10724. https://periodicos.unifor.br/RBPS/article/view/10724.
Xavier AR, Silva JS, Almeida JP, et al. COVID-19: manifestações clínicas e laboratoriais na infecção pelo novo coronavírus. J Bras Patol Med Lab. 2020;56:e3232020. Doi: 10.5935/1676-2444.20200049. http://www.gnresearch.org/doi/10.5935/1676-2444.20200049.
Guo YR, Cao QD, Hong ZS, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res. 2020;7(1):11. Doi: 10.1186/s40779-020-00240-0. https://mmrjournal.biomedcentral.com/articles/10.1186/s40779-020-00240-0.
World Health Organization. Clinical management of severe acute respiratory infection when COVID-19 is suspected. Interim Guidance, 13 Mar 2020. https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected.
Centers for Disease Control and Prevention. Assessing Risk Factors for Severe COVID-19 Illness. COVID-19, 30 Nov 2020. https://www.cdc.gov/coronavirus/2019-ncov/covid-data/investigations-discovery/assessing-risk-factors.html.
Wynants L, Van Calster B, Collins GS, et al. Prediction models for diagnosis and prognosis of COVID-19: systematic review and critical appraisal. BMJ. 2020;369:m1328. Doi: 10.1136/bmj.m1328. https://www.bmj.com/content/369/bmj.m1328.
Gupta RK, Harrison EM, Ho A, Docherty AB, Knight SR, van Smeden M, et al. Systematic evaluation and external validation of 22 prognostic models among hospitalised adults with COVID-19: An observational cohort study. Eur Respir J. 2020 Sep 25; Doi: 10.1183/13993003.03498-2020. https://erj.ersjournals.com/content/early/2020/09/17/13993003.03498-2020.
Knight SR, Ho A, Pius R, Buchan I, Carson G, Drake TM, et al. Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score. BMJ. 2020;370:m3339. Doi: 10.1136/bmj.m3339. https://www.bmj.com/content/370/bmj.m3339.
Ministério da Saúde. COVID-19: Painel Coronavírus. Brasil, 2021. https://covid.saude.gov.br.
Organização Pan-Americana da Saúde. Histórico da pandemia de COVID-19. 11 mar. 2020. https://www.paho.org/pt/covid19/historico-da-pandemia-covid-19.
Wynants L, Sotgiu G. Improving clinical management of COVID-19: the role of prediction models. Lancet Respir Med. 2021;9(11):1219-21. Doi: 10.1016/S2213-2600(21)00006-0. https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(21)00006-0/fulltext.
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054-62. Doi: 10.1016/S0140-6736(20)30566-3.
Smits SL, de Lang A, van den Brand JM, Leijten LM, van IJcken WF, Eijkemans MJC, et al. Exacerbated innate host response to SARS-CoV in aged non-human primates. PLoS Pathog. 2010;6(2):e1000756. Doi:10.1371/journal.ppat.1000756. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1000756.
Petrilli CM, Jones SA, Yang J, Rajagopalan H, O'Donnell L, Chernyak Y, et al. Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City. BMJ. 2020;369:m1966. Doi:10.1136/bmj.m1966. https://www.bmj.com/content/369/bmj.m1966.
Földi M, Farkas N, Kiss S, Zádori N, Váncsa S, Szakó L, et al. Obesity is a risk factor for developing critical condition in COVID-19 patients: A systematic review and meta-analysis. Obes Rev. 2020;21(10):e13095. Doi: 10.1111/obr.13095.
Guan WJ, Liang WH, Zhao Y, Liang HR, Chen ZS, Li YM, et al. Comorbidity and its impact on 1590 patients with Covid-19 in China: a nationwide analysis. Eur Respir J. 2020;55(5):2000547. Doi:10.1183/13993003.00547-2020.
Knight SR, Gupta RK, Ho A, Pius R, Buchan I, Carson G, et al. Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol. Thorax. 2022;77(6):606-15. Doi:10.1136/thoraxjnl-2021-217629.
Wellbelove Z, Walsh C, Perinpanathan T, Lillie P, Barlow G. Comparing the 4C mortality score for COVID-19 to established scores (CURB65, CRB65, qSOFA, NEWS) for respiratory infection patients. J Infect. 2021;82(3):414-51. Doi: 10.1016/j.jinf.2020.10.015.
Fiocruz. Boletim extraordinário 30 de março de 2021. Observatório COVID-19. https://portal.fiocruz.br/observatorio-covid-19.
Lazar Neto F, Marino LO, Torres A, Cilloniz C, Meirelles Marchini JF, Garcia de Alencar JC, et al. Community-acquired pneumonia severity assessment tools in patients hospitalized with COVID-19: a validation and clinical applicability study. Clin Microbiol Infect. 2021;27(7):1037.e1-1037.e8. Doi: 10.1016/j.cmi.2021.03.002.
van Dam PMEL, Zelis N, van Kuijk SMJ, Linkens AEMJH, Brüggemann RAG, Spaetgens B, van der Horst ICC, Stassen PM. Performance of prediction models for short-term outcome in COVID-19 patients in the emergency department: a retrospective study. Ann Med. 2021;53(1):402-9. Doi: 10.1080/07853890.2021.1891453.
Doğanay F, Ak R. Performance of the CURB-65, ISARIC-4C and COVID-GRAM scores in terms of severity for COVID-19 patients. Int J Clin Pract. 2021;75(10):e14759. Doi: 10.1111/ijcp.14759. https://onlinelibrary.wiley.com/doi/full/10.1111/ijcp.14759.
Ong SWX, Sutjipto S, Lee PH, Dugan C, Khoo BY, Ren D, et al. Validation of ISARIC 4C Mortality and Deterioration Scores in a Mixed Vaccination Status Cohort of Hospitalized Coronavirus Disease 2019 (COVID-19) Patients in Singapore. Clin Infect Dis. 2022;75(1):e874-e877. Doi: 10.1093/cid/ciac087.
Kuroda S, Matsumoto S, Sano T, Kitai T, Yonetsu T, Kohsaka S, et al. External validation of the 4C Mortality Score for patients with COVID-19 and pre-existing cardiovascular diseases/risk factors. BMJ Open. 2021;11(9):e052708. Doi: 10.1136/bmjopen-2021-052708.
Ocho K, Hagiya H, Hasegawa K, Fujita K, Otsuka F. Clinical Utility of 4C Mortality Scores among Japanese COVID-19 Patients: A Multicenter Study. J Clin Med. 2022;11(3):821. Doi: 10.3390/jcm11030821.
Morello F, Bima P, Giamello JD, Baricocchi D, Risi F, Vesan M, et al. Study Investigators. A 4C mortality score based dichotomic rule supports Emergency Department discharge of COVID-19 patients. Minerva Med. 2022;113(6):916-26. Doi: 10.23736/S0026-4806.21.07779-X.
Jones A, Pitre T, Junek M, Kapralik J, Patel R, Feng E, et al. Investigators. External validation of the 4C mortality score among COVID-19 patients admitted to hospital in Ontario, Canada: a retrospective study. Sci Rep. 2021;11(1):18638. Doi: 10.1038/s41598-021-97332-1.
Gordon AJ, Govindarajan P, Bennett CL, Matheson L, Kohn MA, Camargo C, et al. External validation of the 4C Mortality Score for hospitalised patients with COVID-19 in the RECOVER network. BMJ Open. 2022;12(4):e054700. Doi: 10.1136/bmjopen-2021-054700.
Riley JM, Moeller PJ, Crawford AG, Schaefer JW, Cheney-Peters DR, Venkataraman CM, Li CJ, et al. External validation of the COVID-19 4C mortality score in an urban United States cohort. Am J Med Sci. 2022;364(4):409-13. Doi: 10.1016/j.amjms.2022.04.030.
Aletreby WT, Mumtaz SA, Shahzad SA, Ahmed I, Alodat MA, Gharba M, et al. External Validation of 4C ISARIC Mortality Score in Critically ill COVID-19 Patients from Saudi Arabia. Saudi J Med Med Sci. 2022;10(1):19-24. Doi: 10.4103/sjmms.sjmms_480_21.
Wirth A, Goetschi A, Held U, Sendoel A, Stuessi-Helbling M, Huber LC. External Validation of the Modified 4C Deterioration Model and 4C Mortality Score for COVID-19 Patients in a Swiss Tertiary Hospital. Diagnostics (Basel). 2022;12(5):1129. Doi: 10.3390/diagnostics12051129.
Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373-83. Doi:10.1016/0021-9681(87)90171-8. https://pubmed.ncbi.nlm.nih.gov/3558716/.
Dean AG, Sullivan KM, Soe MM. OpenEpi: Open Source Epidemiologic Statistics for Public Health. www.OpenEpi.com.
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