Effect of hypomagnesemia and magnesium supplementation on postischemic renal failure

Authors

  • Josenalva Cassiano da Silva Universidade de São Paulo, Faculdade de Medicina
  • Antonio Carlos Seguro Universidade de São Paulo, Faculdade de Medicina

DOI:

https://doi.org/10.11606/issn.1679-9836.v81i1-4p1-7

Keywords:

Wistar, Rats, Kidney failure, acute/physiopathology, Magnesium deficiency/complication, Dietary supplemments/adverse effects, Ischemy/complications.

Abstract

Hypothesis:The aim of this study is to verify the effect of hypomagnesemia and magnesium supplementation on postischemic renal failure. Methods: Five groups of male Wistar rats were studied: control; posthypomagnesemic;
post-ischemic; postischemic + hypomagnesemia and post-ischemic + magnesium supplementation. Clearance and hemodynamic measurements were performed.Results: In postischemic rats, hypomagnesemia induces a marked decrease in GFR, RBF and increases the RVR. In rats with Magnesium supplementation increased GFR and decreased FeH2O were observed when compared with rats on a normal
diet.Conclusion: Hypomagnesemia potentiates postischemic renal failure and magnesium supplementation protects
against renal ischemia.

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Author Biographies

  • Josenalva Cassiano da Silva, Universidade de São Paulo, Faculdade de Medicina
    Acadêmica da FMUSP.
  • Antonio Carlos Seguro, Universidade de São Paulo, Faculdade de Medicina
    Prof. Dr. Livre-Docente da Disciplina de Nefrologia da FMUSP (orientador).

References

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Published

2002-12-20

Issue

Vol. 81 No. 1-4 (2002)

Section

Artigos

How to Cite

Silva, J. C. da, & Seguro, A. C. (2002). Effect of hypomagnesemia and magnesium supplementation on postischemic renal failure. Revista De Medicina, 81(1-4), 1-7. https://doi.org/10.11606/issn.1679-9836.v81i1-4p1-7