Systematic review of islet allotransplantation in rodents: analysis of transplantation site and survival time

Abstract

Introduction. The scarcity of islets is an important use of pancreatic islets for the development of allograft for the treatment of diabetes type I. It is therefore necessary to develop unlimited source of insulin-producing cells restriction. Objectives. Organize and analyze parameters related to the site of transplantation and survival time related to experimental rodent allotransplantation attempts in order to allow the elaboration of the most suitable model to supply the scarcity of islet donors. Methodology. We performed a systematic review using the PubMed database to search published articles containing the keywords “rodent islet transplantation”. We included studies involving allotransplantation experiments with rodents’ islets and we reviewed the reference lists of the publications retrieved that were eligible. We excluded articles related to isotransplantation, autotransplantation and xenotransplantation such as transplantation in other species. Articles related to isotransplantations, transplantations and xenografts were excluded from the study. Results. A total of 30 related allografts in different sites of graft studies were selected for the systematic review based on their relevance data and update. The liver and the kidney capsule are sites that showed better survival of transplanted islets. Conclusion. Allograft transplantation in rodents is promising and continues to develop in several centers. The allograft survival rates increased with the use of different drugs and graft sites.