Intermediate levels of BNP were related with cardiology events in acute coronary syndromes?

Abstract

Introduction: Several studies in the literature
have linked high levels of brain natriuretic peptide (BNP) with
poor prognosis in patients with acute coronary syndrome (ACS).
However, values between 100 pg/ml and 400 pg/ml are considered
borderline and also questioned about the occurrence of events and
diagnosis. Methods: This is an observational retrospective study
to evaluate the BNP intermediate value at hospital admission
can predict in-hospital prognosis. The patients were divided into
two groups: Group I: BNP < 100 pg/ml; Group II: 100 < BNP <
400 pg/mL. It included 405 patients (235 in group I and 170 in
group II) with ACS. Data were obtained regarding comorbidities
and medications used. Statistical analysis: The primary outcome
was mortality from all causes. The secondary endpoint was
combined events (cardiogenic shock, reinfarction, death, stroke
and bleeding). The comparison between groups was performed
using Q-square test and ANOVA. Multivariate analysis was
performed by logistic regression, considering significant p < 0.05.
Results: Comparing the groups I and II, there were differences in
the prevalence of diabetes and previous coronary angioplasty. In
multivariate analysis, there were significant differences between
groups I and II in the occurrence of cardiogenic shock (2.55%
vs. 10.59%, OR = 4.09, p = 0.01), respectively. Conclusion:
Intermediate BNP values were not able to predict mortality in
patients with ACS. However, there was a higher incidence of
cardiogenic shock.