Gastric bipartition for palliative treatment of advanced stomach cancer
case report
DOI:
https://doi.org/10.11606/issn.1679-9836.v99i2p202-208Keywords:
Stomach neoplasms, Palliative care, Case reportsAbstract
Introductions: Gastric Cancer (GC) is the fourth most commonly diagnosed cancer and the second leading cause of cancer death worldwide. Median survival rarely exceeds 12 months, and, in metastatic form, 5-year survival is less than 10%. Most patients present an advanced stage of the disease, often with obstructive and unresectable distal tumors, requiring palliative treatment, whose objective is to give the patient a higher quality of life. Case Report: A 59 years old male patient, retired, smoker, alcoholic. The patient went to the emergency room with post-prandial vomits, associated to epigastric pain and loss of approximately 8 kgs in the last 20 days. In the physical exam, a palpable mass was identified in the epigastrium and mesogastrium, painful and solid. The patient had as an initial diagnostic hypothesis of pyloric syndrome secondary to gastric neoplasia. CT scan of the abdomen showed presence of a solid expansive process, infiltrative, involving the gastric wall, in the antrum, inclusive promoting signs of liquid stasis. A heterogeneous nodule in contact with the inferior vena cava, with 1.1 x 0.9 cm in its biggest diameters. With the diagnosis of advanced gastric adenocarcinoma, with invasion of the inferior vena cava, pancreas and hepatic metastasis, with no curative surgical or oncological intervention, it was opted to feed the patient with parenteral nutrition. The surgical team opted for the gastric bipartition with gastrojejunostomy, open technique, with total surgical time of 90 minutes. Patient was discharged in the fourth POD, in good clinical conditions, good oral intake, with no nausea or vomits. The patient died 16 months after the surgery due to gastric hemorrhage secondary to the advanced tumor and sepsis. Conclusão: The technique of bipartition can be considered an effective and safe technique, providing fewer symptoms, such as nausea and vomiting, oral diet maintenance and quality of life for patients who doesn´t have a curative intervention.
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References
Dicken BJ, Bigam DL, Cass C, Mackey JR, Joy AA, Hamilton SM. Gastric adenocarcinoma: review and considerations for future directions. An Surg. 2005;241(1):27-39. doi: 10.1097/01.sla.0000149300.28588.23.
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69-90. doi: 10.3322/caac.20107.
Hanahan D, Weinberg RA. The Hallmarks of Cancer. Cell. 2000;100(1):57-70. doi: https://doi.org/10.1016/S0092-8674(00)81683-9.
Hartgrink HH, Jansen EP, van Grieken NC, van de Velde CJ. Gastric cancer. Lancet. 2009;374(9688):477-90. doi: 10.1016/S0140-6736(09)60617-6.
Kumagai K, Rouvelas I, Ernberg A, Persson S, Analatos A, Mariosa D, et al. A systematic review and meta-analysis comparing partial stomach partitioning gastrojejunostomy versus conventional gastrojejunostomy for malignant gastroduodenal obstruction. Langenbeck’s Arch Surg. 2016;401(6):777-85. doi: 10.1007/s00423-016-1470-8.
Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 2006;24(14):2137-50. doi: 10.1200/JCO.2005.05.2308.
Mendes de Almeida JC, Bettencourt, A, Santos Costa C, Mendes de Almeida JM. Cirurgia paliativa por carcinoma do estômago. Estudo retrospectivo de 112 casos. Acta Med Port. 1992;6:55-8. Disponível em: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/download/3065/2407.
Cola CB, Linhares E, Kesley R, Pinto CE. Tratamento cirúrgico do câncer gástrico em pacientes jovens: experiência de 05 anos no INCA. Rev Bras Cancerol. 2005;51(2):135-41. Disponível em: https://rbc.inca.gov.br/site/arquivos/n_51/v02/pdf/artigo5.pdf.
Fujitani K, Yamada M, Hirao M, Kurokawa Y, Tsujinaka T. Optimal indications of surgical palliation for incurable advanced gastric cancer presenting with malignant gastrointestinal obstruction. Gastric Cancer. 2011;14(4):353-9. doi: 10.1007/s10120-011-0053-1.
Jeurnink SM, Steyerberg EW, van Hooft JE, van Eijck CH, Schwartz MP, Vleggaar FP, et al. Surgical gastrojejunostomy or endoscopic stent placement for the palliation of malignant gastric outlet obstruction (SUSTENT study): a multicenter randomized trial. Gastroint Endosc. 2010;71(3):490-9. doi: 10.1016/j.gie.2009.09.042.
Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature. 1998;396(6712):643-9. doi: 10.1038/25292.
Potz BA, Brittany TJ. Surgical palliation of gastric outlet obstruction in advanced malignancy. World J Gastroint Surg. 2016;8(8):545-55. doi: 10.4240/wjgs.v8.i8.545.
Coimbra BG, Ramos MF, Yagi O, Jacob C, Cecconello I, Zilbertein B. Partição gástrica para o tratamento paliativo de pacientes com tumores gástricos distais obstrutivos e irresecáveis. Rev Med (São Paulo). 2015;94(1):21-8. https://doi.org/10.11606/issn.1679-9836.v94i1p21-28.
Orditura M, Galizia G, Sforza V, Gambardella V, Fabozzi A, Laterza MM, et al. Treatment of gastric cancer. World J Gastroenterol. 2014;20(7):1635-49. doi: 10.3748/wjg.v20.i7.1635.
Hosono S, Ohtani H, Arimoto Y, Kanamiya Y. Endoscopic stenting versus surgical gastroenterostomy for palliation of malignant gastroduodenal obstruction: a meta-analysis. J Gastroenterol. 2007;42(4):283-90. doi: 10.1007/s00535-006-2003-y.
Nagaraja V, Eslick GD, Cox MR. Endoscopic stenting versus operative gastrojejunostomy for malignant gastric outlet obstruction-a systematic review and meta-analysis of randomized and non-randomized trials. J Gastroint Oncol. 2014;5(2):92-8. doi: 10.3978/j.issn.2078-6891.2014.016.
Fernandez AO, Manchado FCP, Plaza AG, Delgado AA. Gastro yeyuno anastomosis com separación gástrica parcial en el tratamiento de la obstrucción gastroduodenal secundaria a cáncer gástrico avanzado. Cir Ciruj (Mex). 2015;83(5):386-92. doi: 10.1016/j.circir.2015.05.034.
Fernández-Moreno MC, Martí-Obiol R, López F, Ortega J. Modified devine exclusion for unresectable distal gastric cancer in symptomatic patients. Case Rep Gastroenterol. 2017;11(1):9-16. doi: 10.1159/000452759.
Shimonosono M, Ishigami S, Arigami T, Uenosono Y, Uchikado Y, Kita Y, et al. A case report of curative distal gastrectomy for stage IV gastric cancer after chemoradiotherapy in a patient with a gastrojejunal gastric bypass. Surg Case Rep. 2016;2(1):131. doi: 10.1186/s40792-016-0259-x.
Souza FO, Antunes LCM, Trabalho LURS. Tratamento paliativo do adenocarcinoma gástrico. ABCD Arq Bras Cir Dig. 2011;24(1):74-80. doi: 10.1590/S0102-67202011000100016.
Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205-13. doi: 10.1097/01.sla.0000133083.54934.ae.