cute hepatitis secondary to abuse of cocaine, associated with severe rhabdomyolysis
DOI:
https://doi.org/10.11606/issn.1679-9836.v99i2p189-196Keywords:
Cocaine, Hepatotoxicity, Acute Kidney Injury, Rhabdomolysis, Chemical and drug induced liver injuryAbstract
Cocaine is a drug with a noticeable ability to adversely affect almost every organ in the body and can cause a multitude of secondary multisystem abnormalities. In the present study, we report three cases of acute liver failure complicated by rhabdomyolysis and acute kidney injury following cocaine and alcohol use. The disease onset, clinical manifestations, laboratory data, diagnosis and treatment of each patient were recorded. Note the presence of multifactorial causes for the occurrence of liver failure and rhabdomyolysis in the three reported cases. Laboratory tests revealed that serum trasaminases as well as creatine phosphokinase (CPK) concentrations increased, and symptoms of acute renal failure were present, which provided an accurate diagnosis of acute liver failure complicated by severe rhabdomyolysis and acute renal injury. dialytic rhabdomyolysis is a condition of hypermyoglobinuria, being one of the main factors that promote a deterioration of renal function. Early phase therapy involved support for volume resuscitation associated with dialysis therapy with strict control of renal function. All three patients developed multiple organ involvement, but only one died due to the severity of the condition. Considering the three cases presented, we conclude that liver failure, complicated by rhabdomyolysis, secondary to cocaine and alcohol use may have a poor clinical prognosis, depending on several factors. And doctors should be aware of the potential effects caused by cocaine in order to manage the multiple complications associated with substance abuse.
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