Alternativas terapêuticas e aplicação de bacteriófagos como estratégia no uso de antibióticos no tratamento de doenças bacterianas

Abstract

Resistance to treatment of different microorganisms has been considered a major concern in the public health and medical fields. Pharmacological, microbiological, immunological approaches and the search for therapeutic alternatives have gained prominence in this area in order to understand the theme. In this context, the objective was to compile information correlating with alternative therapies with the problem of bacterial diseases in view of the multidrug resistance developed by antibiotic superbugs, since they represent the main treatment used in patients with these comorbidities. The electronic bases used as facilitators of the theme included SciELO, PubMed, MEDLINE and LILACS, period 2010-2019. From the active approaches, it is observed that the expansion of the therapeutic collection and prolongation of treatment to all periods of the natural process of bacterial diseases, avoiding the imminent seclusion regarding the offer of treatments to the most distinct cases of resistance, is considered a differential aspect. Still, aiming at solving this impasse, seeking effective therapeutic alternatives in the treatment of the most varied cases of bacterial diseases, and the possibility of its execution, either exclusively or mainly complementary to the use of antibiotics. Multiple intervention possibilities have been considered to include haemofiltration devices, quorum detection inhibitors, advanced immunotherapies, bacteriophage use, alternative efforts to limit virulence, integrative medicine measures such as homeopathy and herbal medicine. After the analysis, it was concluded that due to its efficacy and selective mechanism of action among the therapeutic alternatives found, the most promising was the application of bacteriophages.